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anti-PKC-beta II antibody :: anti-Rat PKC-beta II Antibody

Scan QR to view Datasheet Catalog #    MBS480064 anti-PKC-beta II antibody
Unit / Price
0.1 mL  /  $250 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PKC-beta II, Antibody

 Also Known As   

Anti-Rat PKC-beta II

 Product Gene Name   

anti-PKC-beta II antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176970
 3D Structure    ModBase 3D Structure for P05771
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 Species Reactivity    Rat
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 Preparation and Storage    At -70 degree C
 Other Notes    Small volumes of anti-PKC-beta II antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PKC-beta II. It may not necessarily be applicable to this product.
 NCBI GI #    20141488
 NCBI GeneID    5579
 NCBI Accession #    P05771.4 [Other Products]
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 UniProt Primary Accession #    P05771 [Other Products]
 UniProt Secondary Accession #    O43744; P05127; Q15138; Q93060; Q9UE49; Q9UE50; Q9UEH8; Q9UJ30; Q9UJ33; C5IFJ8; D3DWF5 [Other Products]
 UniProt Related Accession #    P05771 [Other Products]
 Molecular Weight    77,012 Da
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 NCBI Official Full Name    Protein kinase C beta type
 NCBI Official Synonym Full Names    protein kinase C, beta
 NCBI Official Symbol    PRKCB [Similar Products]
 NCBI Official Synonym Symbols   
PKCB; PRKCB1; PRKCB2; PKC-beta
[Similar Products]
 NCBI Protein Information    protein kinase C beta type; PKC-B; protein kinase C, beta 1 polypeptide
 UniProt Protein Name    Protein kinase C beta type
 UniProt Gene Name    PRKCB [Similar Products]
 UniProt Synonym Gene Names    PKCB; PRKCB1; PKC-B; PKC-beta [Similar Products]
 UniProt Entry Name    KPCB_HUMAN
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 NCBI Summary for PKC-beta II    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PKC-beta II    PKCB: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic receptors. Activates the NF-kappaB signaling pathway in B cells after antigen-receptor signaling. Two splice-variant isoforms have been described.

Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 2.7.11.13; Kinase, protein; AGC group; PKC family; Alpha subfamily

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; membrane; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; androgen receptor binding; protein kinase C binding; ligand-dependent nuclear receptor transcription coactivator activity; zinc ion binding; histone binding; calcium channel regulator activity; chromatin binding; ATP binding

Biological Process: platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; B cell activation; transcription, DNA-dependent; apoptosis; positive regulation of B cell receptor signaling pathway; mitotic nuclear envelope disassembly; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; activation of NF-kappaB transcription factor; regulation of transcription from RNA polymerase II promoter; cellular calcium ion homeostasis; synaptic transmission; B cell receptor signaling pathway; positive regulation of angiogenesis; lipoprotein transport; calcium ion transport; response to hypoxia; mitotic cell cycle; vascular endothelial growth factor receptor signaling pathway; blood coagulation
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 Research Articles on PKC-beta II    1. PKCbeta2 inhibition protects mice from gut ischemia-reperfusion injury by suppressing the adaptor p66(Shc)-mediated oxidative stress and subsequent apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PKC-beta II antibodyDiseases associated with anti-PKC-beta II antibody
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >5 publications with PKC-beta II and Cardiovascular Diseases
 Kidney Diseases Antibodies  >5 publications with PKC-beta II and Kidney Diseases
 Diabetes Mellitus, Type 2 Antibodies  >5 publications with PKC-beta II and Diabetes Mellitus, Type 2
 Hyperglycemia Antibodies  >5 publications with PKC-beta II and Hyperglycemia
 Nervous System Diseases Antibodies  >3 publications with PKC-beta II and Nervous System Diseases
 Inflammation Antibodies  >3 publications with PKC-beta II and Inflammation
 Autistic Disorder Antibodies  >3 publications with PKC-beta II and Autistic Disorder
 Colorectal Neoplasms Antibodies  >3 publications with PKC-beta II and Colorectal Neoplasms
 Disease Models, Animal Antibodies  >3 publications with PKC-beta II and Disease Models, Animal
 Breast Neoplasms Antibodies  >2 publications with PKC-beta II and Breast Neoplasms
Organs/Tissues associated with anti-PKC-beta II antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with PKC-beta II and Blood
 Kidney Antibodies  >6 publications with PKC-beta II and Kidney
 Brain Antibodies  >6 publications with PKC-beta II and Brain
 Bone Antibodies  >3 publications with PKC-beta II and Bone
 Heart Antibodies  >3 publications with PKC-beta II and Heart
 Lung Antibodies  >3 publications with PKC-beta II and Lung
 Bone Marrow Antibodies  >2 publications with PKC-beta II and Bone Marrow
 Eye Antibodies  >2 publications with PKC-beta II and Eye
 Skin Antibodies  >1 publications with PKC-beta II and Skin
 Uterus Antibodies  >1 publications with PKC-beta II and Uterus
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