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anti-PKC antibody :: Rabbit PKC zeta Antibody

Scan QR to view Datasheet Catalog #    MBS855992
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PKC zeta, Antibody

 Also Known As   

PKC zeta (Phospho-Thr410) Antibody

 Product Synonym Names    EC 2.7.11.13; KPCZ; PKC-zeta; PKC2; PRKCZ; Protein kinase C zeta type; kinase PKC-zeta; nPKC-zeta
 Product Gene Name   

anti-PKC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176982
 3D Structure    ModBase 3D Structure for Q05513
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    PKCzeta (phospho-Thr410) antibody detects endogenous levels of PKCzeta only when phosphorylated at threonine 410.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human PKCzeta around the phosphorylation site of threonine 410 (T-S-TP-F-C).
 All Sites    Human: Thr410; Mouse: Thr410; Rat: Thr410
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-PKC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PKC antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-PKC antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-PKC antibody    WB: 1:500~1000, IHC: 1:50~100, IF: 1:100~1:500, ELISA: 1:20000
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 Testing Data of anti-PKC antibody    P-peptide - +
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PKCzeta (phospho-Thr410) antibody.
anti-PKC antibody Testing Data image
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 Testing Data #2 of anti-PKC antibody    Western blot analysis of extracts from NIH/3T3 cells treated with PMA (125ng/ml, 30mins), using PKCzeta (phospho-Thr410) antibody.
anti-PKC antibody Testing Data #2 image
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 Testing Data #3 of anti-PKC antibody    P-peptide - +
Immunofluorescence analysis of HeLa cells, using PKCzeta (phospho-Thr410) antibody.
anti-PKC antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for PKC. It may not necessarily be applicable to this product.
 NCBI GI #    75709226
 NCBI GeneID    5590
 NCBI Accession #    NP_001028753.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001033581.1 [Other Products]
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 UniProt Primary Accession #    Q05513 [Other Products]
 UniProt Secondary Accession #    Q15207; Q5SYT5; Q969S4; A8K4N0; A8MU64; B7Z2J7; E9PCW2 [Other Products]
 UniProt Related Accession #    Q05513 [Other Products]
 Molecular Weight    56,136 Da
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 NCBI Official Full Name    protein kinase C zeta type isoform 2
 NCBI Official Synonym Full Names    protein kinase C, zeta
 NCBI Official Symbol    PRKCZ [Similar Products]
 NCBI Official Synonym Symbols   
PKC2; PKC-ZETA
[Similar Products]
 NCBI Protein Information    protein kinase C zeta type; nPKC-zeta
 UniProt Protein Name    Protein kinase C zeta type
 UniProt Synonym Protein Names   
nPKC-zeta
 UniProt Gene Name    PRKCZ [Similar Products]
 UniProt Synonym Gene Names    PKC2 [Similar Products]
 UniProt Entry Name    KPCZ_HUMAN
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 NCBI Summary for PKC    Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PKC    PKCZ: an AGC kinase of the PKC family. An atypical PKC: its activity is not regulated by Ca2+, PS, DAG or phorbol esters. Constitutively active.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; Protein kinase, AGC; AGC group; PKC family; Iota subfamily

Chromosomal Location of Human Ortholog: 1p36.33-p36.2

Cellular Component: tight junction; nuclear matrix; apical cortex; leading edge; nuclear envelope; intercellular junction; cytosol; lipid raft; axon hillock; filamentous actin; membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; plasma membrane; microtubule organizing center; cell junction; endosome

Molecular Function: protein serine/threonine kinase activity; protein domain specific binding; protein binding; phospholipase binding; protein kinase C activity; potassium channel regulator activity; insulin receptor substrate binding; metal ion binding; protein kinase binding; ATP binding; protein kinase activity

Biological Process: protein heterooligomerization; membrane hyperpolarization; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; positive regulation of interleukin-4 production; positive regulation of glucose import; positive regulation of T-helper 2 cell differentiation; negative regulation of hydrolase activity; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; vesicle transport along microtubule; inflammatory response; positive regulation of cell-matrix adhesion; platelet activation; negative regulation of peptidyl-tyrosine phosphorylation; phospholipase D activation; cell migration; activation of protein kinase B; microtubule cytoskeleton organization and biogenesis; peptidyl-serine phosphorylation; long-term memory; establishment of cell polarity; actin cytoskeleton reorganization; insulin receptor signaling pathway; positive regulation of insulin receptor signaling pathway; blood coagulation; vascular endothelial growth factor receptor signaling pathway; negative regulation of protein complex assembly; negative regulation of apoptosis
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Product References and Citations for anti-PKC antibody

   Todd E. Fox, J. Biol. Chem., Feb 2007; 10.1074/jbc.M700082200.
Katherine A. Fitzgerald, J. Immunol., Feb 2000; 164: 2053.
Koichi Asanuma, J. Immunol., Mar 2004; 172: 3922.
Ashish Bhattacharjee, J. Immunol., Sep 2006; 177: 3771 - 3781.
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 Research Articles on PKC    1. These data indicate for the first time that HIV-1 Gag phosphorylation on Ser487 is mediated by atypical PKC and that this kinase may regulate the incorporation of Vpr into HIV-1 virions and thereby supports virus infectivity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PKC antibodyPathways associated with anti-PKC antibody
 Reference Product  PubMed Publications
 PARD3 antibody  >2 publications with PKC and PARD3
 AKT1 antibody  >2 publications with PKC and AKT1
 PARD6A antibody  >2 publications with PKC and PARD6A
 CDC42 antibody  >1 publications with PKC and CDC42
 PDPK1 antibody  >1 publications with PKC and PDPK1
 RELA antibody  >1 publications with PKC and RELA
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with anti-PKC antibodyOrgans/Tissues associated with anti-PKC antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >4 publications with PKC and Heart Diseases
 Nervous System Diseases Antibodies  >3 publications with PKC and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >3 publications with PKC and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with PKC and Hypertrophy
 Leukemia Antibodies  >2 publications with PKC and Leukemia
 Prostatic Neoplasms Antibodies  >2 publications with PKC and Prostatic Neoplasms
 Fatty Liver Antibodies  >1 publications with PKC and Fatty Liver
 Edema Antibodies  >1 publications with PKC and Edema
 Kidney Diseases Antibodies  >1 publications with PKC and Kidney Diseases
 Inflammation Antibodies  >1 publications with PKC and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >10 publications with PKC and Liver
 Heart Antibodies  >8 publications with PKC and Heart
 Brain Antibodies  >8 publications with PKC and Brain
 Kidney Antibodies  >4 publications with PKC and Kidney
 Lung Antibodies  >3 publications with PKC and Lung
 Eye Antibodies  >3 publications with PKC and Eye
 Prostate Antibodies  >2 publications with PKC and Prostate
 Uterus Antibodies  >2 publications with PKC and Uterus
 Ovary Antibodies  >1 publications with PKC and Ovary
 Lymph Antibodies  >1 publications with PKC and Lymph
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