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anti-PKC zeta antibody :: PKC zeta Antibody

Scan QR to view Datasheet Catalog #    MBS855992
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PKC zeta, Antibody

 Also Known As   

PKC zeta (Phospho-Thr410) Antibody

 Product Synonym Names    EC 2.7.11.13; KPCZ; PKC-zeta; PKC2; PRKCZ; Protein kinase C zeta type; kinase PKC-zeta; nPKC-zeta
 Product Gene Name   

anti-PKC zeta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176982
 3D Structure    ModBase 3D Structure for Q05513
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    PKC zeta (phospho-Thr410) antibody detects endogenous levels of PKC zeta only when phosphorylated at threonine 410.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human PKC zeta around the phosphorylation site of threonine 410 (T-S-TP-F-C).
 All Sites    Human: Thr410
Mouse: Thr410
Rat: Thr410
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-PKC zeta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PKC zeta antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-PKC zeta antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-PKC zeta antibody    WB: 1:500~1000
IHC: 1:50~100
IF: 1:100~1:500
ELISA: 1:20000
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 Immunohistochemistry (IHC) of anti-PKC zeta antibody    P-peptide-+ Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PKC zeta (phospho-Thr410) antibody.
anti-PKC zeta antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-PKC zeta antibody    Western blot analysis of extracts from NIH/3T3 cells treated with PMA (125ng/ml, 30mins), using PKC zeta (phospho-Thr410) antibody.
anti-PKC zeta antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-PKC zeta antibody    P-peptide-+ Immunofluorescence analysis of HeLa cells, using PKC zeta (phospho-Thr410) antibody.
anti-PKC zeta antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for PKC zeta. It may not necessarily be applicable to this product.
 NCBI GI #    75709226
 NCBI GeneID    5590
 NCBI Accession #    NP_001028753.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001033581.2 [Other Products]
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 UniProt Primary Accession #    Q05513 [Other Products]
 UniProt Secondary Accession #    Q15207; Q5SYT5; Q969S4; A8K4N0; A8MU64; B7Z2J7; E9PCW2 [Other Products]
 UniProt Related Accession #    Q05513 [Other Products]
 Molecular Weight    56,136 Da
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 NCBI Official Full Name    protein kinase C zeta type isoform 2
 NCBI Official Synonym Full Names    protein kinase C zeta
 NCBI Official Symbol    PRKCZ [Similar Products]
 NCBI Official Synonym Symbols   
PKC2; PKC-ZETA
[Similar Products]
 NCBI Protein Information    protein kinase C zeta type
 UniProt Protein Name    Protein kinase C zeta type
 UniProt Synonym Protein Names   
nPKC-zeta
 UniProt Gene Name    PRKCZ [Similar Products]
 UniProt Synonym Gene Names    PKC2 [Similar Products]
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 NCBI Summary for PKC zeta    Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PKC zeta    Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).
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Product References and Citations for anti-PKC zeta antibody

   Todd E. Fox, J. Biol. Chem., Feb 2007; 10.1074/jbc.M700082200. Katherine A. Fitzgerald, J. Immunol., Feb 2000; 164: 2053. Koichi Asanuma, J. Immunol., Mar 2004; 172: 3922. Ashish Bhattacharjee, J. Immunol., Sep 2006; 177: 3771-3781.
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 Research Articles on PKC zeta    1. Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine remarkably attenuated gut injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2, which was phosphorylated by PKCzeta at Ser(55), but not at Ser(11), under intestinal I/R or H/R conditions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PKC zeta antibodyPathways associated with anti-PKC zeta antibody
 Reference Product  PubMed Publications
 PRKCD antibody  >4 publications with PKC zeta and PRKCD
 PRKCA antibody  >3 publications with PKC zeta and PRKCA
 MAPK1 antibody  >2 publications with PKC zeta and MAPK1
 IRS1 antibody  >2 publications with PKC zeta and IRS1
 PARD6A antibody  >2 publications with PKC zeta and PARD6A
 NUMB antibody  >1 publications with PKC zeta and NUMB
 MAPK3 antibody  >1 publications with PKC zeta and MAPK3
 MAP2K5 antibody  >1 publications with PKC zeta and MAP2K5
 IKBKB antibody  >1 publications with PKC zeta and IKBKB
 HRAS antibody  >1 publications with PKC zeta and HRAS
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with anti-PKC zeta antibodyOrgans/Tissues associated with anti-PKC zeta antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >4 publications with PKC zeta and Heart Diseases
 Cardiovascular Diseases Antibodies  >3 publications with PKC zeta and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >2 publications with PKC zeta and Nervous System Diseases
 Hypertrophy Antibodies  >2 publications with PKC zeta and Hypertrophy
 Prostatic Neoplasms Antibodies  >2 publications with PKC zeta and Prostatic Neoplasms
 Seizures Antibodies  >1 publications with PKC zeta and Seizures
 Kidney Diseases Antibodies  >1 publications with PKC zeta and Kidney Diseases
 Edema Antibodies  >1 publications with PKC zeta and Edema
 Fatty Liver Antibodies  >1 publications with PKC zeta and Fatty Liver
 Inflammation Antibodies  >1 publications with PKC zeta and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >10 publications with PKC zeta and Liver
 Heart Antibodies  >7 publications with PKC zeta and Heart
 Brain Antibodies  >5 publications with PKC zeta and Brain
 Kidney Antibodies  >4 publications with PKC zeta and Kidney
 Lung Antibodies  >3 publications with PKC zeta and Lung
 Eye Antibodies  >3 publications with PKC zeta and Eye
 Prostate Antibodies  >2 publications with PKC zeta and Prostate
 Uterus Antibodies  >2 publications with PKC zeta and Uterus
 Ovary Antibodies  >1 publications with PKC zeta and Ovary
 Lymph Antibodies  >1 publications with PKC zeta and Lymph
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