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anti-PKCdelta antibody :: PKCdelta Antibody

Scan QR to view Datasheet Catalog #    MBS856672
Unit / Price
0.05 mg  /  $180 +1 FREE 8GB USB
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PKCdelta, Antibody

★Popular Item★
 Also Known As   

PKCdelta (Ab-645) Antibody

 Product Synonym Names    PRKCD; Protein kinase C delta type
 Product Gene Name   

anti-PKCdelta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176977
 3D Structure    ModBase 3D Structure for Q05655
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    PKCdelta (Ab-645) antibody detects endogenous levels of total PKCdelta protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human PKCdelta around the phosphorylation site of serine 645 (R-L-SP-Y-S).
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-PKCdelta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PKCdelta antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-PKCdelta antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PKCdelta antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
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 Immunohistochemistry (IHC) of anti-PKCdelta antibody    Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PKCdelta (Ab-645) antibody.
anti-PKCdelta antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-PKCdelta antibody    Western blot analysis of extracts from MCF7 cells using PKCdelta (Ab-645) antibody and PKCdelta (phospho-Ser645) antibody.
anti-PKCdelta antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PKCdelta. It may not necessarily be applicable to this product.
 NCBI GI #    938403365
 NCBI GeneID    5580
 NCBI Accession #    NP_001303256.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001316327.1 [Other Products]
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 UniProt Primary Accession #    Q05655 [Other Products]
 UniProt Secondary Accession #    Q15144; Q86XJ6; B0KZ81; B2R834 [Other Products]
 UniProt Related Accession #    Q05655 [Other Products]
 Molecular Weight    80,953 Da
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 NCBI Official Full Name    protein kinase C delta type
 NCBI Official Synonym Full Names    protein kinase C delta
 NCBI Official Symbol    PRKCD [Similar Products]
 NCBI Official Synonym Symbols   
MAY1; PKCD; ALPS3; CVID9; nPKC-delta
[Similar Products]
 NCBI Protein Information    protein kinase C delta type
 UniProt Protein Name    Protein kinase C delta type
 UniProt Synonym Protein Names   
Tyrosine-protein kinase PRKCD (EC:2.7.10.2); nPKC-delta
 Protein Family    Putative protein kinase
 UniProt Gene Name    PRKCD [Similar Products]
 UniProt Synonym Gene Names    SDK1 [Similar Products]
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 NCBI Summary for PKCdelta    The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]
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 UniProt Comments for PKCdelta    Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462).
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Product References and Citations for anti-PKCdelta antibody

   Kei Sakamoto, et, al. (2003) Am J Physiol Endocrinol Metab, ; 285: E1081-E1088. Ling Zhang, et, al. (2004) J. Biol. Chem; 279: 28315-28319. Kristof Van Kolen et, al. (2006) FEBS J; 273: 1843-1854. Martin Villalba, et, al. (2002) J. Cell Biol; 157: 253.
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 Research Articles on PKCdelta    1. NRF2 Ser40 phosphorylation was inhibited in Crif1-deficient bone marrow multipotent mesenchymal stromal cells even in the presence of three kinds of PKC agonists, suggesting that CRIF1 might co-activate PKC-delta to phosphorylate NRF2 Ser40.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PKCdelta antibodyPathways associated with anti-PKCdelta antibody
 Reference Product  PubMed Publications
 SRC antibody  >64 publications with PKCdelta and SRC
 MAPK1 antibody  >36 publications with PKCdelta and MAPK1
 RHOA antibody  >12 publications with PKCdelta and RHOA
 STAT1 antibody  >11 publications with PKCdelta and STAT1
 PRKCQ antibody  >10 publications with PKCdelta and PRKCQ
 STAT3 antibody  >10 publications with PKCdelta and STAT3
 FYN antibody  >8 publications with PKCdelta and FYN
 IRS1 antibody  >6 publications with PKCdelta and IRS1
 PIK3CA antibody  >1 publications with PKCdelta and PIK3CA
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
Diseases associated with anti-PKCdelta antibodyOrgans/Tissues associated with anti-PKCdelta antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >51 publications with PKCdelta and Necrosis
 Heart Diseases Antibodies  >49 publications with PKCdelta and Heart Diseases
 Nervous System Diseases Antibodies  >40 publications with PKCdelta and Nervous System Diseases
 Disease Models, Animal Antibodies  >37 publications with PKCdelta and Disease Models, Animal
 Inflammation Antibodies  >36 publications with PKCdelta and Inflammation
 Hypertrophy Antibodies  >24 publications with PKCdelta and Hypertrophy
 Breast Neoplasms Antibodies  >23 publications with PKCdelta and Breast Neoplasms
 Adenocarcinoma Antibodies  >22 publications with PKCdelta and Adenocarcinoma
 Cardiomyopathies Antibodies  >17 publications with PKCdelta and Cardiomyopathies
 Intestinal Neoplasms Antibodies  >16 publications with PKCdelta and Intestinal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >149 publications with PKCdelta and Blood
 Heart Antibodies  >96 publications with PKCdelta and Heart
 Vascular Antibodies  >78 publications with PKCdelta and Vascular
 Brain Antibodies  >74 publications with PKCdelta and Brain
 Nerve Antibodies  >38 publications with PKCdelta and Nerve
 Kidney Antibodies  >34 publications with PKCdelta and Kidney
 Lung Antibodies  >32 publications with PKCdelta and Lung
 Liver Antibodies  >31 publications with PKCdelta and Liver
 Skin Antibodies  >28 publications with PKCdelta and Skin
 Bone Antibodies  >23 publications with PKCdelta and Bone
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