NP_000919.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,360 Da
NCBI Official Full Name
phospholipase A2
NCBI Official Synonym Full Names
phospholipase A2 group IB
NCBI Protein Information
phospholipase A2
UniProt Protein Name
Phospholipase A2
UniProt Synonym Protein Names
Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B
UniProt Synonym Gene Names
NCBI Summary for PLA2G1B
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
UniProt Comments for PLA2G1B
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Research Articles on PLA2G1B
Precautions
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Disclaimer
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Products associated with anti-PLA2G1B antibody
Pathways associated with anti-PLA2G1B antibody
Diseases associated with anti-PLA2G1B antibody
Organs/Tissues associated with anti-PLA2G1B antibody
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