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anti-PLCG1 antibody :: Rabbit PLCG1 (Phospho-Tyr771) Antibody

Scan QR to view Datasheet Catalog #    MBS001020 anti-PLCG1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLCG1 (Phospho-Tyr771), Antibody

 Also Known As   

Rabbit PLCG1 (Phospho-Tyr771) Antibody

 Product Gene Name   

anti-PLCG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (39766161..39804357). Location: 20q12-q13.1
 OMIM    172420
 3D Structure    ModBase 3D Structure for P19174
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-PLCG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PLCG1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PLCG1. It may not necessarily be applicable to this product.
 NCBI GI #    33598948
 NCBI GeneID    5335
 NCBI Accession #    NP_002651.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002660.2 [Other Products]
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 UniProt Primary Accession #    P19174 [Other Products]
 UniProt Secondary Accession #    Q2V575; B7ZLY7; B9EGH4; E1P5W4 [Other Products]
 UniProt Related Accession #    P19174 [Other Products]
 Molecular Weight    148,532 Da
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 NCBI Official Full Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform a
 NCBI Official Synonym Full Names    phospholipase C, gamma 1
 NCBI Official Symbol    PLCG1 [Similar Products]
 NCBI Official Synonym Symbols   
PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
[Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-gamma-1; phospholipase C-II; phospholipase C-148; phosphoinositidase C; phospholipase C-gamma-1; inositoltrisphosphohydrolase; phosphoinositide phospholipase C; phosphatidylinositol phospholipase C; triphosphoinositide phosphodiesterase; phosphoinositide phospholipase C-gamma-1; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; phospholipase C, gamma 1 (formerly subtype 148); 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
 UniProt Protein Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
 UniProt Synonym Protein Names   
PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1
 Protein Family    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
 UniProt Gene Name    PLCG1 [Similar Products]
 UniProt Synonym Gene Names    PLC1; PLC-II; PLC-gamma-1 [Similar Products]
 UniProt Entry Name    PLCG1_HUMAN
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 NCBI Summary for PLCG1    The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLCG1    PLCG1: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.

Protein type: EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 20q12-q13.1

Cellular Component: signalosome; ruffle; cell projection; lamellipodium; cytoplasm; plasma membrane; intercellular junction; cytosol

Molecular Function: glutamate receptor binding; protein binding; neurotrophin TRKA receptor binding; receptor signaling protein activity; calcium ion binding; receptor tyrosine kinase binding; protein kinase binding; phosphoinositide phospholipase C activity; phospholipase C activity

Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; cell migration; fibroblast growth factor receptor signaling pathway; inositol phosphate metabolic process; nerve growth factor receptor signaling pathway; viral reproduction; activation of MAPKK activity; in utero embryonic development; phospholipid catabolic process; cytokine and chemokine mediated signaling pathway; positive regulation of blood vessel endothelial cell migration; calcium-mediated signaling; signal transduction; T cell receptor signaling pathway; positive regulation of angiogenesis; phospholipase C activation; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; blood coagulation; vascular endothelial growth factor receptor signaling pathway; leukocyte migration
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 Research Articles on PLCG1    1. High expression of PLCgamma1, and of its activated forms, is associated with a worse clinical outcome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLCG1 antibodyPathways associated with anti-PLCG1 antibody
 Reference Product  PubMed Publications
 SRC antibody  >10 publications with PLCG1 and SRC
 FYN antibody  >4 publications with PLCG1 and FYN
 SYK antibody  >4 publications with PLCG1 and SYK
 EGFR antibody  >4 publications with PLCG1 and EGFR
 LAT antibody  >4 publications with PLCG1 and LAT
 ZAP70 antibody  >2 publications with PLCG1 and ZAP70
 SOS2 antibody  >2 publications with PLCG1 and SOS2
 SOS1 antibody  >2 publications with PLCG1 and SOS1
 LCK antibody  >2 publications with PLCG1 and LCK
 ITK antibody  >2 publications with PLCG1 and ITK
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
Diseases associated with anti-PLCG1 antibodyOrgans/Tissues associated with anti-PLCG1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with PLCG1 and Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with PLCG1 and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with PLCG1 and Inflammation
 Neoplasms, Experimental Antibodies  >2 publications with PLCG1 and Neoplasms, Experimental
 Heart Diseases Antibodies  >2 publications with PLCG1 and Heart Diseases
 Drug Toxicity Antibodies  >2 publications with PLCG1 and Drug Toxicity
 Necrosis Antibodies  >2 publications with PLCG1 and Necrosis
 Cardiomyopathies Antibodies  >1 publications with PLCG1 and Cardiomyopathies
 Brain Diseases Antibodies  >1 publications with PLCG1 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with PLCG1 and Blood
 Brain Antibodies  >7 publications with PLCG1 and Brain
 Muscle Antibodies  >6 publications with PLCG1 and Muscle
 Vascular Antibodies  >6 publications with PLCG1 and Vascular
 Heart Antibodies  >4 publications with PLCG1 and Heart
 Liver Antibodies  >4 publications with PLCG1 and Liver
 Bone Antibodies  >4 publications with PLCG1 and Bone
 Lung Antibodies  >3 publications with PLCG1 and Lung
 Kidney Antibodies  >3 publications with PLCG1 and Kidney
 Embryonic Tissue Antibodies  >3 publications with PLCG1 and Embryonic Tissue
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