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Add To Compare List anti-PLGF antibody :: Mouse PLGF (Placental Growth Factor) Monoclonal Antibody Catalog # MBS4380154 Unit / Price 0.02 mg (With BSA & Azide at 0.2mg/mL) / $240 +1 FREE 8GB USB 0.1 mg (With BSA & Azide at 0.2mg/mL) / $415 +1 FREE 8GB USB 0.1 mg (Without BSA & Azide at 1mg/mL) / $415 +1 FREE 8GB USB 5x0.1 mg (With BSA & Azide at 0.2mg/mL) / $1,735 +2 FREE 8GB USB 5x0.1 mg (Without BSA & Azide at 1mg/mL) / $1,735 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name PLGF (Placental Growth Factor), Monoclonal Antibody Popular Item Full Product Name PLGF (Placental Growth Factor) Product Synonym Names PGFL; PIGF; placental growth factor (PGF); Vascular endothelial growth factor related protein Product Gene Name anti-PLGF antibody[Similar Products] Product Synonym Gene Name PGF[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP 3D Structure ModBase 3D Structure for P49763 Clonality Monoclonal Isotype IgG1, kappa Clone Number PLGF/93 Host Mouse Species Reactivity Human. Others not known. Specificity The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Serum levels of PLGF in some cases are used as a potential biomarker for disease or genetic defect. Recent research indicates that PLGF levels are lower in mothers with Down syndrome fetuses. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR. Form/Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. Immunogen Recombinant human PLGF protein Cellular Localization Secreted (extracellular) Hu-chromosome Location 14q24.3 Positive Control HepG2 or HEK293T cells. Human placental and brain tumors. Preparation and Storage Antibody with azide - store at 2 to 8 degree C.Antibody without azide - store at -20 to -80 degree C.Antibody is stable for 24 months. Non-hazardous. No MSDS required. Other Notes Small volumes of anti-PLGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Applications Tested/Suitable for anti-PLGF antibody ELISA (EIA), Functional Studies Application Notes for anti-PLGF antibody ELISA: For coating, order Ab without BSA.Functional Studies: Order Ab without BSA & Azide. Immunohistochemistry (IHC) of anti-PLGF antibody Formalin-paraffin human Prostate Carcinoma stained with TDP2 MAb (TDP2/1258) TOP NCBI/Uniprot data below describe general gene information for PLGF. It may not necessarily be applicable to this product. NCBI GI # 333033785 NCBI GeneID 5228 NCBI Accession # NP_001193941.1 [Other Products] NCBI GenBank Nucleotide # NM_001207012.1 [Other Products] UniProt Primary Accession # P49763 [Other Products] UniProt Secondary Accession # Q07101; Q9BV78; Q9Y6S8[Other Products] UniProt Related Accession # P49763[Other Products] Molecular Weight 18kDa TOP NCBI Official Full Name placenta growth factor isoform 2 NCBI Official Synonym Full Names placental growth factor NCBI Official Symbol PGF [Similar Products] NCBI Official Synonym Symbols PGFL; PIGF; PLGF; PlGF-2; D12S1900; SHGC-10760 [Similar Products] NCBI Protein Information placenta growth factor UniProt Protein Name Placenta growth factor UniProt Gene Name PGF [Similar Products] UniProt Synonym Gene Names PGFL; PLGF; PlGF [Similar Products] TOP NCBI Summary for PLGF This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011] TOP UniProt Comments for PLGF Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Product References and Citations for anti-PLGF antibody Beiswenger TR et al. The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin. Reprod Sci 19:526-33 (2012). Xu HX et al. Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue. Int J Cancer 128:1559-69 (2011). Research Articles on PLGF 1. Recombinant hPlGF-2 significantly improved contractile function and reduced LV end-systolic and end-diastolic volume indices with a concomitant increase in capillary and arteriolar density in ischemic myocardium, without aggravating atherosclerosis. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-PLGF antibody Reference Product PubMed Publications VEGFA antibody >20 publications with PLGF and VEGFA FLT1 antibody >15 publications with PLGF and FLT1 IL6 antibody >12 publications with PLGF and IL6 KDR antibody >8 publications with PLGF and KDR FLT4 antibody >2 publications with PLGF and FLT4 AKT1 antibody >1 publications with PLGF and AKT1 PIK3CA antibody >1 publications with PLGF and PIK3CA NRP1 antibody >1 publications with PLGF and NRP1 Pathways associated with anti-PLGF antibody Products by Pathway Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram PI3K-Akt Signaling Pathway antibodies PI3K-Akt Signaling Pathway Diagram PI3K-Akt Signaling Pathway antibodies PI3K-Akt Signaling Pathway Diagram Pathways In Cancer antibodies Pathways In Cancer Diagram Signal Transduction Pathway antibodies Signal Transduction Pathway Diagram Signaling By VEGF Pathway antibodies Signaling By VEGF Pathway Diagram VEGF Binds To VEGFR Leading To Receptor Dimerization Pathway antibodies VEGF Binds To VEGFR Leading To Receptor Dimerization Pathway Diagram VEGF Ligand-receptor Interactions Pathway antibodies VEGF Ligand-receptor Interactions Pathway Diagram Diseases associated with anti-PLGF antibody Disease Name Pubmed Publications Cardiovascular Diseases Antibodies >369 publications with PLGF and Cardiovascular Diseases Inflammation Antibodies >274 publications with PLGF and Inflammation Hypertension Antibodies >191 publications with PLGF and Hypertension Disease Models, Animal Antibodies >155 publications with PLGF and Disease Models, Animal Neoplasms Antibodies >150 publications with PLGF and Neoplasms Necrosis Antibodies >148 publications with PLGF and Necrosis Heart Diseases Antibodies >123 publications with PLGF and Heart Diseases Atherosclerosis Antibodies >89 publications with PLGF and Atherosclerosis Drug Toxicity Antibodies >80 publications with PLGF and Drug Toxicity Brain Diseases Antibodies >69 publications with PLGF and Brain Diseases Organs/Tissues associated with anti-PLGF antibody Organ/Tissue Name Pubmed Publications Ovary Antibodies >748 publications with PLGF and Ovary Uterus Antibodies >720 publications with PLGF and Uterus Muscle Antibodies >497 publications with PLGF and Muscle Heart Antibodies >241 publications with PLGF and Heart Lung Antibodies >233 publications with PLGF and Lung Kidney Antibodies >210 publications with PLGF and Kidney Placenta Antibodies >199 publications with PLGF and Placenta Embryonic Tissue Antibodies >195 publications with PLGF and Embryonic Tissue Brain Antibodies >194 publications with PLGF and Brain Liver Antibodies >133 publications with PLGF and Liver TOP © 2006-24 MyBioSource.com. 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