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anti-PLK1 antibody :: Rabbit PLK1 (Phospho-Thr210) Antibody

Scan QR to view Datasheet Catalog #    MBS003348 anti-PLK1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLK1 (Phospho-Thr210), Antibody

 Also Known As   

Rabbit PLK1 (Phospho-Thr210) Antibody

 Product Gene Name   

anti-PLK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (23690201..23701688). Location: 16p12.2
 OMIM    602098
 3D Structure    ModBase 3D Structure for P53350
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-PLK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PLK1 antibody   

Immunohistochemistry (IHC), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for PLK1. It may not necessarily be applicable to this product.
 NCBI GI #    21359873
 NCBI GeneID    5347
 NCBI Accession #    NP_005021.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005030.3 [Other Products]
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 UniProt Primary Accession #    P53350 [Other Products]
 UniProt Secondary Accession #    Q15153; Q99746 [Other Products]
 UniProt Related Accession #    P53350 [Other Products]
 Molecular Weight    68,255 Da
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 NCBI Official Full Name    serine/threonine-protein kinase PLK1
 NCBI Official Synonym Full Names    polo-like kinase 1
 NCBI Official Symbol    PLK1 [Similar Products]
 NCBI Official Synonym Symbols   
PLK; STPK13
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase PLK1; PLK-1; polo like kinase; polo (Drosophia)-like kinase; serine/threonine-protein kinase 13; cell cycle regulated protein kinase
 UniProt Protein Name    Serine/threonine-protein kinase PLK1
 UniProt Synonym Protein Names   
Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    PLK1 [Similar Products]
 UniProt Synonym Gene Names    PLK; PLK-1; STPK13 [Similar Products]
 UniProt Entry Name    PLK1_HUMAN
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 NCBI Summary for PLK1    The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
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 UniProt Comments for PLK1    PLK1: a kinase of the PLK family. Contains a polo-box domain (PBD), a specific phosphoserine or phosphothreonine binding domain. Substrates include BRCA2, Myt1, NudC, Cdc25C, cyclin B1, Nlp and other mitotic proteins. Inhibited by ATR. Plays a role in regulation of cytokinesis and coordinating M-phase events.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.21; Protein kinase, Other; Kinase, protein; Other group; PLK family

Chromosomal Location of Human Ortholog: 16p12.2

Cellular Component: spindle pole; centrosome; cytosol; nucleoplasm; kinetochore; microtubule cytoskeleton; spindle microtubule; cytoplasm; nucleolus; spindle; midbody; spindle midzone; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; microtubule binding; kinase activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of cell cycle; positive regulation of proteolysis; regulation of mitotic cell cycle; mitotic nuclear envelope disassembly; cytokinesis; protein ubiquitination; anaphase-promoting complex activation during mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; response to antibiotic; establishment of protein localization; cytokinesis after mitosis; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; centrosome organization and biogenesis; positive regulation of ubiquitin-protein ligase activity; mitotic cell cycle spindle assembly checkpoint; G2/M transition of mitotic cell cycle; mitosis; mitotic sister chromatid segregation; protein destabilization; organelle organization and biogenesis; regulation of mitotic metaphase/anaphase transition; negative regulation of cyclin-dependent protein kinase activity; cell proliferation; peptidyl-serine phosphorylation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of protein binding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; polar body extrusion after meiotic divisions; mitotic cell cycle; G2/M transition DNA damage checkpoint; microtubule bundle formation; mitotic metaphase/anaphase transition; negative regulation of apoptosis
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 Research Articles on PLK1    1. Plk1 phosphorylates MISP, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLK1 antibodyPathways associated with anti-PLK1 antibody
 Reference Product  PubMed Publications
 CCNB1 antibody  >79 publications with PLK1 and CCNB1
 CDC25C antibody  >62 publications with PLK1 and CDC25C
 TP53 antibody  >23 publications with PLK1 and TP53
 WEE1 antibody  >22 publications with PLK1 and WEE1
 BUB1 antibody  >19 publications with PLK1 and BUB1
 PRC1 antibody  >11 publications with PLK1 and PRC1
 MYT1 antibody  >10 publications with PLK1 and MYT1
 MCM2 antibody  >8 publications with PLK1 and MCM2
 BRCA2 antibody  >7 publications with PLK1 and BRCA2
 PIN1 antibody  >7 publications with PLK1 and PIN1
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Activation Of NIMA Kinases NEK9, NEK6, NEK7 Pathway antibodies  Activation Of NIMA Kinases NEK9, NEK6, NEK7 Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
Diseases associated with anti-PLK1 antibodyOrgans/Tissues associated with anti-PLK1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >300 publications with PLK1 and Neoplasms
 Carcinoma Antibodies  >96 publications with PLK1 and Carcinoma
 Breast Neoplasms Antibodies  >40 publications with PLK1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >29 publications with PLK1 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >28 publications with PLK1 and Cell Transformation, Neoplastic
 Drug Toxicity Antibodies  >22 publications with PLK1 and Drug Toxicity
 Liver Neoplasms Antibodies  >19 publications with PLK1 and Liver Neoplasms
 Disease Models, Animal Antibodies  >18 publications with PLK1 and Disease Models, Animal
 Liver Diseases Antibodies  >17 publications with PLK1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >16 publications with PLK1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >41 publications with PLK1 and Lung
 Liver Antibodies  >23 publications with PLK1 and Liver
 Prostate Antibodies  >23 publications with PLK1 and Prostate
 Blood Antibodies  >23 publications with PLK1 and Blood
 Bone Antibodies  >19 publications with PLK1 and Bone
 Brain Antibodies  >15 publications with PLK1 and Brain
 Skin Antibodies  >13 publications with PLK1 and Skin
 Kidney Antibodies  >13 publications with PLK1 and Kidney
 Stomach Antibodies  >12 publications with PLK1 and Stomach
 Thyroid Antibodies  >11 publications with PLK1 and Thyroid
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