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anti-POLH antibody :: Rabbit POLH Antibody

Scan QR to view Datasheet Catalog #    MBS8501893
Testing Data
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

POLH, Antibody

★Popular Item★
 Also Known As   

POLH Antibody

 Product Synonym Names    FLJ16395; FLJ21978; RAD30; RAD30A; XP-V; XPV
 Product Gene Name   

anti-POLH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    278750
 3D Structure    ModBase 3D Structure for Q9Y253
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human POLH
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-POLH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-POLH antibody

   This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008]
 Product Categories/Family for anti-POLH antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-POLH antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-POLH antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Testing Data of anti-POLH antibody    Western blot analysis of extracts of A431cell lines, using POLH antibody.
anti-POLH antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for POLH. It may not necessarily be applicable to this product.
 NCBI GI #    634743306
 NCBI GeneID    5429
 NCBI Accession #    NP_001278899.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291970.1 [Other Products]
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 UniProt Primary Accession #    Q9Y253 [Other Products]
 UniProt Secondary Accession #    Q7L8E3; Q96BC4; Q9BX13 [Other Products]
 UniProt Related Accession #    Q9Y253 [Other Products]
 Molecular Weight    78kDa
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 NCBI Official Full Name    DNA polymerase eta isoform 3
 NCBI Official Synonym Full Names    DNA polymerase eta
 NCBI Official Symbol    POLH [Similar Products]
 NCBI Official Synonym Symbols   
XPV; XP-V; RAD30; RAD30A
[Similar Products]
 NCBI Protein Information    DNA polymerase eta
 UniProt Protein Name    DNA polymerase eta
 UniProt Synonym Protein Names   
RAD30 homolog A; Xeroderma pigmentosum variant type protein
 Protein Family    DNA polymerase
 UniProt Gene Name    POLH [Similar Products]
 UniProt Synonym Gene Names    RAD30; RAD30A; XPV [Similar Products]
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 NCBI Summary for POLH    This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
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 UniProt Comments for POLH    DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586).
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 Research Articles on POLH    1. POLH & POLK are both able to exchange with PolD1 stalled at repetitive CFS (common fragile sites) sequences. POLD1 synthesis was inhibited by replication stress caused by aphidicolin, preventing any replication past CFS. Importantly, POLH & POLK were still proficient in rescuing this stalled POLD1 synthesis. POLD1 stalling at CFSs allows for free exchange with specialized polymerase that is not driven by PCNA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-POLH antibodyPathways associated with anti-POLH antibody
 Reference Product  PubMed Publications
 XPA antibody  >10 publications with POLH and XPA
 REV1 antibody  >10 publications with POLH and REV1
 PCNA antibody  >10 publications with POLH and PCNA
 REV3L antibody  >5 publications with POLH and REV3L
 RAD18 antibody  >4 publications with POLH and RAD18
 RCHY1 antibody  >3 publications with POLH and RCHY1
 OGG1 antibody  >1 publications with POLH and OGG1
 UBC antibody  >1 publications with POLH and UBC
 Products by Pathway  Pathway Diagram
 DNA Damage Bypass Pathway antibodies  DNA Damage Bypass Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway antibodies  HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway Diagram
 HDR Through Homologous Recombination (HRR) Pathway antibodies  HDR Through Homologous Recombination (HRR) Pathway Diagram
 Homology Directed Repair Pathway antibodies  Homology Directed Repair Pathway Diagram
 Termination Of Translesion DNA Synthesis Pathway antibodies  Termination Of Translesion DNA Synthesis Pathway Diagram
 Translesion Synthesis By POLH Pathway antibodies  Translesion Synthesis By POLH Pathway Diagram
Diseases associated with anti-POLH antibodyOrgans/Tissues associated with anti-POLH antibody
 Disease Name  Pubmed Publications
 Xeroderma Pigmentosum Antibodies  >46 publications with POLH and Xeroderma Pigmentosum
 Inflammation Antibodies  >4 publications with POLH and Inflammation
 Adenocarcinoma Antibodies  >3 publications with POLH and Adenocarcinoma
 Anemia Antibodies  >2 publications with POLH and Anemia
 Cell Transformation, Neoplastic Antibodies  >2 publications with POLH and Cell Transformation, Neoplastic
 Chromosome Aberrations Antibodies  >2 publications with POLH and Chromosome Aberrations
 Brain Diseases Antibodies  >1 publications with POLH and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with POLH and Nervous System Diseases
 Colonic Neoplasms Antibodies  >1 publications with POLH and Colonic Neoplasms
 Kidney Diseases Antibodies  >1 publications with POLH and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >32 publications with POLH and Skin
 Blood Antibodies  >19 publications with POLH and Blood
 Kidney Antibodies  >2 publications with POLH and Kidney
 Lymph Node Antibodies  >2 publications with POLH and Lymph Node
 Embryonic Tissue Antibodies  >1 publications with POLH and Embryonic Tissue
 Liver Antibodies  >1 publications with POLH and Liver
 Mouth Antibodies  >1 publications with POLH and Mouth
 Eye Antibodies  >1 publications with POLH and Eye
 Bone Marrow Antibodies  >1 publications with POLH and Bone Marrow
 Bone Antibodies  >1 publications with POLH and Bone
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