NP_055317.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
55,181 Da
NCBI Official Full Name
pre-mRNA-processing factor 19
NCBI Official Synonym Full Names
pre-mRNA processing factor 19
NCBI Official Synonym Symbols
PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200 [Similar Products]
NCBI Protein Information
pre-mRNA-processing factor 19; PRP19/PSO4 homolog; senescence evasion factor; nuclear matrix protein 200; PRP19/PSO4 pre-mRNA processing factor 19 homolog; nuclear matrix protein NMP200 related to splicing factor PRP19
UniProt Protein Name
Pre-mRNA-processing factor 19
UniProt Synonym Protein Names
Nuclear matrix protein 200; PRP19/PSO4 homolog; hPso4; Senescence evasion factor
UniProt Synonym Gene Names
UniProt Entry Name
PRP19_HUMAN
NCBI Summary for PRPF19
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]
UniProt Comments for PRPF19
PRPF19: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Belongs to the WD repeat PRP19 family.
Protein type: RNA splicing; Ubiquitin conjugating system; Ligase; EC 6.3.2.-; Spliceosome; Ubiquitin ligase; EC 6.3.2.19
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: nucleoplasm; DNA replication factor A complex; membrane; cytoplasm; spindle; nuclear speck; lipid particle; nucleus
Molecular Function: identical protein binding; protein binding; ligase activity
Biological Process: positive regulation of nuclear mRNA splicing, via spliceosome; assembly of spliceosomal tri-snRNP; nuclear mRNA splicing, via spliceosome; proteasomal protein catabolic process; negative regulation of neuron differentiation; protein polyubiquitination; RNA splicing; lipid biosynthetic process; spliceosome assembly; gene expression; generation of catalytic spliceosome for first transesterification step; inner cell mass cell proliferation; double-strand break repair via nonhomologous end joining; positive regulation of astrocyte differentiation
Research Articles on PRPF19
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Pathways associated with anti-PRPF19 antibody
Diseases associated with anti-PRPF19 antibody
Organs/Tissues associated with anti-PRPF19 antibody
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