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anti-PTK7 antibody :: Mouse anti-Human PTK7 Antibody

Scan QR to view Datasheet Catalog #    MBS850252
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PTK7, Antibody

 Also Known As   

PTK7 Antibody

 Product Synonym Names    CCK4; PTK7
 Product Gene Name   

anti-PTK7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601890
 3D Structure    ModBase 3D Structure for Q13308
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 Isotype    IgG1
 Clone Number    4F9
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of human PTK7 expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C.
 Other Notes    Small volumes of anti-PTK7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PTK7 antibody

   Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
 Product Categories/Family for anti-PTK7 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-PTK7 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-PTK7 antibody    WB: 1:500-1:2000
IHC: 1:200-1:1000
ELISA: 1:10000
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 Western Blot (WB) of anti-PTK7 antibody    Figure 1: Western blot analysis using PTK7 mouse mAb against Hela (1), A431 (2), HCT116 (3), Caco2 (4), HepG2 (5) and MCF-7 (6) cell lysate.
anti-PTK7 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PTK7 antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer tissues using PTK7 mouse mAb with DAB staining.
anti-PTK7 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PTK7. It may not necessarily be applicable to this product.
 NCBI GI #    393715082
 NCBI GeneID    5754
 NCBI Accession #    NP_001257327.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270398.1 [Other Products]
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 UniProt Primary Accession #    Q13308 [Other Products]
 UniProt Secondary Accession #    Q13417; Q5T650; Q6IQ54; Q8NFA5; Q8NFA6; Q8NFA7; Q8NFA8; A8K974; B7Z477; E9PFZ5 [Other Products]
 UniProt Related Accession #    Q13308 [Other Products]
 Molecular Weight    118kDa
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 NCBI Official Full Name    inactive tyrosine-protein kinase 7 isoform e
 NCBI Official Synonym Full Names    protein tyrosine kinase 7 (inactive)
 NCBI Official Symbol    PTK7 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    inactive tyrosine-protein kinase 7
 UniProt Protein Name    Inactive tyrosine-protein kinase 7
 UniProt Synonym Protein Names   
Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7
 Protein Family    Inactive tyrosine-protein kinase
 UniProt Gene Name    PTK7 [Similar Products]
 UniProt Synonym Gene Names    CCK4; CCK-4 [Similar Products]
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 NCBI Summary for PTK7    This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
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 UniProt Comments for PTK7    Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
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 Research Articles on PTK7    1. Inhibition of PTK7 by siRNA treatment significantly decreases the viability of atypical teratoid rhabdoid tumors (ATRT)patient-derived tumor cell lines.These studies provide the groundwork for future preclinical in vivo studies aiming to investigate the efficacy of PTK7 inhibition on ATRT tumor growth
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-PTK7 antibodyOrgans/Tissues associated with anti-PTK7 antibody
 Disease Name  Pubmed Publications
 Neural Tube Defects Antibodies  >6 publications with PTK7 and Neural Tube Defects
 Carcinoma, Hepatocellular Antibodies  >1 publications with PTK7 and Carcinoma, Hepatocellular
 Esophageal Neoplasms Antibodies  >1 publications with PTK7 and Esophageal Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with PTK7 and Neoplasm Metastasis
 Thyroid Neoplasms Antibodies  >1 publications with PTK7 and Thyroid Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with PTK7 and Brain
 Lung Antibodies  >8 publications with PTK7 and Lung
 Embryonic Tissue Antibodies  >6 publications with PTK7 and Embryonic Tissue
 Blood Antibodies  >5 publications with PTK7 and Blood
 Liver Antibodies  >4 publications with PTK7 and Liver
 Bone Antibodies  >4 publications with PTK7 and Bone
 Thymus Antibodies  >3 publications with PTK7 and Thymus
 Stomach Antibodies  >3 publications with PTK7 and Stomach
 Vascular Antibodies  >3 publications with PTK7 and Vascular
 Pancreas Antibodies  >2 publications with PTK7 and Pancreas
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