NP_000306.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
parathyroid hormone isoform 1 preproprotein
NCBI Official Synonym Full Names
parathyroid hormone
NCBI Official Synonym Symbols
NCBI Protein Information
parathyroid hormone
UniProt Protein Name
Parathyroid hormone
UniProt Synonym Protein Names
Parathormone; Parathyrin
UniProt Synonym Gene Names
UniProt Entry Name
PTHY_HUMAN
NCBI Summary for PTH
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
UniProt Comments for PTH
PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.
Protein type: Hormone; Secreted; Secreted, signal peptide; Apoptosis
Chromosomal Location of Human Ortholog: 11p15.3-p15.1
Cellular Component: extracellular region; extracellular space
Molecular Function: parathyroid hormone receptor binding; peptide hormone receptor binding; RNA polymerase II transcription factor activity, enhancer binding
Biological Process: bone resorption; cAMP metabolic process; G-protein coupled receptor protein signaling pathway; induction of apoptosis by hormones; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; positive regulation of cAMP biosynthetic process; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression; skeletal development
Disease: Hypoparathyroidism, Familial Isolated
Product References and Citations for anti-PTH antibody
Watson, P.H. and Hanley, D.A. 1993. Parathyroid hormone: regulation of synthesis and secretion. Clin. Invest. Med. 16: 58-77.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-PTH antibody
Pathways associated with anti-PTH antibody
Diseases associated with anti-PTH antibody
Organs/Tissues associated with anti-PTH antibody
|