NP_000255.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
144,356 Da
NCBI Official Full Name
protein patched homolog 1 isoform L
NCBI Official Synonym Full Names
patched 1
NCBI Protein Information
protein patched homolog 1
UniProt Protein Name
Protein patched homolog 1
UniProt Synonym Gene Names
NCBI Summary for PTCH
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017]
UniProt Comments for PTCH
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Product References and Citations for anti-PTCH antibody
Trudy G. Oliver, Development, May 2005; 132: 2425-2439. Florence Brellier, Cancer Res., Apr 2004; 64: 2699-2704. Heidi Hahn, J. Biol. Chem., May 1996; 271: 12125. RL Johnson, Development, Dec 1995; 121: 4161.
Research Articles on PTCH
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Products associated with anti-PTCH antibody
Pathways associated with anti-PTCH antibody
Diseases associated with anti-PTCH antibody
Organs/Tissues associated with anti-PTCH antibody
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