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anti-PER2 antibody :: Rabbit anti-Human, mouse Period Circadian Protein 2 (Phospho-Ser662) Antibody

Scan QR to view Datasheet Catalog #    MBS003404 anti-PER2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Period Circadian Protein 2 (Phospho-Ser662) (PER2), Antibody

 Also Known As   

Rabbit Period Circadian Protein 2 (Phospho-Ser662) Antibody

 Product Gene Name   

anti-PER2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (239152679..239197207, complement). Location: 2q37.3
 OMIM    603426
 3D Structure    ModBase 3D Structure for O15055
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-PER2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PER2 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PER2. It may not necessarily be applicable to this product.
 NCBI GI #    12707562
 NCBI GeneID    8864
 NCBI Accession #    NP_073728.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022817.2 [Other Products]
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 UniProt Primary Accession #    O15055 [Other Products]
 UniProt Secondary Accession #    Q4ZG49; Q9UQ45; A2I2P7 [Other Products]
 UniProt Related Accession #    O15055 [Other Products]
 Molecular Weight    136,579 Da [Similar Products]
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 NCBI Official Full Name    period circadian protein homolog 2
 NCBI Official Synonym Full Names    period circadian clock 2
 NCBI Official Symbol    PER2 [Similar Products]
 NCBI Official Synonym Symbols   
FASPS; FASPS1
[Similar Products]
 NCBI Protein Information    period circadian protein homolog 2; hPER2; period 2; period homolog 2; period circadian protein 2; circadian clock protein PERIOD 2
 UniProt Protein Name    Period circadian protein homolog 2
 UniProt Synonym Protein Names   
Circadian clock protein PERIOD 2
 Protein Family    Period circadian protein
 UniProt Gene Name    PER2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0347; hPER2 [Similar Products]
 UniProt Entry Name    PER2_HUMAN
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 NCBI Summary for PER2    This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PER2    PER2: a transcription factor belonging to the basic helix-loop-helix (bHLH) family. A member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hr rhythm in the suprachiasmatic nucleus and the whole eyes. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between per1 and per2 oscillations. The expression rhythms appear to originate from retina.

Protein type: Nucleolus; Transcription factor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: ubiquitin binding; signal transducer activity; protein binding; histone deacetylase binding; transcription coactivator activity; kinase binding; nuclear hormone receptor binding

Biological Process: circadian rhythm; glycogen biosynthetic process; transcription, DNA-dependent; regulation of cell cycle; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; regulation of circadian rhythm; signal transduction; regulation of glutamate uptake during transmission of nerve impulse; gluconeogenesis; regulation of neurogenesis; regulation of vasoconstriction; white fat cell differentiation; lactate biosynthetic process; negative regulation of protein ubiquitination; negative regulation of circadian rhythm; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of insulin secretion

Disease: Advanced Sleep Phase Syndrome, Familial, 1
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 Research Articles on PER2    1. These results provide preliminary evidence for the role of the PER2 gene in regulating striatal D2R availability in the human brain and in vulnerability for cocaine addiction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PER2 antibodyPathways associated with anti-PER2 antibody
 Reference Product  PubMed Publications
 PER1 antibody  >577 publications with PER2 and PER1
 CRY1 antibody  >213 publications with PER2 and CRY1
 PER3 antibody  >166 publications with PER2 and PER3
 CRY2 antibody  >141 publications with PER2 and CRY2
 TIMELESS antibody  >20 publications with PER2 and TIMELESS
 CSNK1E antibody  >7 publications with PER2 and CSNK1E
 CSNK1D antibody  >3 publications with PER2 and CSNK1D
 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies  BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-PER2 antibody
 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >24 publications with PER2 and Drug Toxicity
 Advanced Sleep-Phase Syndrome, Familial Antibodies  >19 publications with PER2 and Advanced Sleep-Phase Syndrome, Familial
 Inflammation Antibodies  >18 publications with PER2 and Inflammation
 Brain Diseases Antibodies  >18 publications with PER2 and Brain Diseases
 Necrosis Antibodies  >13 publications with PER2 and Necrosis
 Liver Diseases Antibodies  >13 publications with PER2 and Liver Diseases
 Liver Neoplasms Antibodies  >12 publications with PER2 and Liver Neoplasms
 Heart Diseases Antibodies  >11 publications with PER2 and Heart Diseases
 Fatty Liver Antibodies  >11 publications with PER2 and Fatty Liver
 Hypertension Antibodies  >10 publications with PER2 and Hypertension
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