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anti-PLCD4 antibody :: Rabbit anti-Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1495166 anti-PLCD4 antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (PLCD4), Polyclonal Antibody

 Also Known As   

Rabbit anti-human 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-4 polyclonal Antibody(PLCD4), HRP conjugated

 Product Synonym Names    hPLCD4; Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4; PLCD4
 Product Gene Name   

anti-PLCD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605939
 3D Structure    ModBase 3D Structure for Q9BRC7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    HRP
 Immunogen    Recombinant human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 protein(1-762AA)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30830 / sc-30063
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PLCD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PLCD4 antibody

   Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
 Applications Tested/Suitable for anti-PLCD4 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for PLCD4. It may not necessarily be applicable to this product.
 NCBI GI #    14249340
 NCBI GeneID    84812
 NCBI Accession #    NP_116115.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_032726.3 [Other Products]
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 UniProt Primary Accession #    Q9BRC7 [Other Products]
 UniProt Secondary Accession #    Q53FS8 [Other Products]
 UniProt Related Accession #    Q9BRC7 [Other Products]
 Molecular Weight    31,448 Da
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 NCBI Official Full Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
 NCBI Official Synonym Full Names    phospholipase C delta 4
 NCBI Official Symbol    PLCD4 [Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
 UniProt Protein Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
 UniProt Synonym Protein Names   
Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4
 Protein Family    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
 UniProt Gene Name    PLCD4 [Similar Products]
 UniProt Synonym Gene Names    hPLCD4; PLC-delta-4 [Similar Products]
 UniProt Entry Name    PLCD4_HUMAN
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 NCBI Summary for PLCD4    This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]
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 UniProt Comments for PLCD4    PLCD4: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; Phospholipase

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cytoplasm; endoplasmic reticulum; nuclear membrane; plasma membrane

Molecular Function: calcium ion binding; phosphoinositide phospholipase C activity; signal transducer activity

Biological Process: acrosome reaction; lipid catabolic process; phosphatidylinositol metabolic process
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 Research Articles on PLCD4    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLCD4 antibodyPathways associated with anti-PLCD4 antibody
 Reference Product  PubMed Publications
 DGKI antibody  >1 publications with PLCD4 and DGKI
 DGKZ antibody  >1 publications with PLCD4 and DGKZ
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol-5-phosphate Metabolism Pathway antibodies  D-myo-inositol-5-phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
Diseases associated with anti-PLCD4 antibodyOrgans/Tissues associated with anti-PLCD4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with PLCD4 and Nervous System Diseases
 Epilepsy Antibodies  >1 publications with PLCD4 and Epilepsy
 Seizures Antibodies  >1 publications with PLCD4 and Seizures
 Breast Neoplasms Antibodies  >1 publications with PLCD4 and Breast Neoplasms
 Brain Diseases Antibodies  >1 publications with PLCD4 and Brain Diseases
 Hypertrophy Antibodies  >1 publications with PLCD4 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with PLCD4 and Testis
 Liver Antibodies  >2 publications with PLCD4 and Liver
 Brain Antibodies  >2 publications with PLCD4 and Brain
 Heart Antibodies  >1 publications with PLCD4 and Heart
 Embryonic Tissue Antibodies  >1 publications with PLCD4 and Embryonic Tissue
 Muscle Antibodies  >1 publications with PLCD4 and Muscle
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