NP_058776.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,732 Da
NCBI Official Full Name
corticosteroid 11-beta-dehydrogenase isozyme 1
NCBI Official Synonym Full Names
hydroxysteroid 11-beta dehydrogenase 1
NCBI Official Synonym Symbols
NCBI Protein Information
corticosteroid 11-beta-dehydrogenase isozyme 1
UniProt Protein Name
Corticosteroid 11-beta-dehydrogenase isozyme 1
UniProt Synonym Protein Names
11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1
UniProt Synonym Gene Names
NCBI Summary for HSD11b1
catalyzes the interconversion of cortisol and cortisone; plays a role in glucocorticoid metabolism; may regulate blood pressure [RGD, Feb 2006]
UniProt Comments for HSD11b1
HSD11B1: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol. Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: EC 1.1.1.146; Endoplasmic reticulum; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Nuclear envelope; Oxidoreductase
Chromosomal Location of Human Ortholog: 13q27
Cellular Component: apical part of cell; cytoplasm; endoplasmic reticulum membrane; integral component of membrane; intracellular membrane-bound organelle; membrane; nuclear membrane; rough endoplasmic reticulum
Molecular Function: 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; NADP binding; steroid binding
Biological Process: glucocorticoid biosynthetic process; glucocorticoid catabolic process; lung development; regulation of pentose-phosphate shunt; response to nutrient levels
Research Articles on HSD11b1
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Pathways associated with anti-HSD11b1 antibody
Diseases associated with anti-HSD11b1 antibody
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