CAA71447.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
Molecular Weight
Calculated MW: 32 Observed MW: 35
NCBI Official Full Name
11-beta-hydroxysteroid dehydrogenase, type 1, partial
UniProt Protein Name
Corticosteroid 11-beta-dehydrogenase isozyme 1
UniProt Synonym Protein Names
11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1
UniProt Synonym Gene Names
UniProt Entry Name
DHI1_RAT
UniProt Comments for 11beta-HSD1
HSD11B1: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol. Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: DNA replication; Membrane protein, integral; RNA-binding; Transferase; Oxidoreductase; Nuclear envelope; Endoplasmic reticulum; EC 1.1.1.146; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen
Cellular Component: apical part of cell; cytoplasm; endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle; membrane; nuclear membrane; rough endoplasmic reticulum
Molecular Function: 11-beta-hydroxysteroid dehydrogenase activity; NADP binding; oxidoreductase activity; steroid binding
Biological Process: glucocorticoid biosynthetic process; glucocorticoid catabolic process; lung development; phthalate metabolic process; regulation of pentose-phosphate shunt; response to nutrient levels
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Diseases associated with anti-11beta-HSD1 antibody
|