NP_006752.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,504 Da
NCBI Official Full Name
14-3-3 protein epsilon
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
NCBI Official Synonym Symbols
MDS; HEL2; MDCR; KCIP-1; 14-3-3E [Similar Products]
NCBI Protein Information
14-3-3 protein epsilon
UniProt Protein Name
14-3-3 protein epsilon
UniProt Synonym Gene Names
UniProt Entry Name
1433E_HUMAN
NCBI Summary for 14-3-3 epsilon
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Comments for 14-3-3 epsilon
14-3-3 epsilon: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: kinesin complex; focal adhesion; cytoplasmic vesicle membrane; membrane; mitochondrion; axon; melanosome; cytosol
Molecular Function: protein domain specific binding; protein binding; enzyme binding; potassium channel regulator activity; protein heterodimerization activity; histone deacetylase binding; phosphoprotein binding; phosphoserine binding
Biological Process: substantia nigra development; viral reproduction; nerve growth factor receptor signaling pathway; apoptosis; organelle organization and biogenesis; hippocampus development; neuron migration; mitotic cell cycle; cerebral cortex development; G2/M transition of mitotic cell cycle; regulation of caspase activity; regulation of the rate of heart contraction by hormone; protein targeting
Disease: Miller-dieker Lissencephaly Syndrome
Research Articles on 14-3-3 epsilon
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Products associated with anti-14-3-3 epsilon antibody
Pathways associated with anti-14-3-3 epsilon antibody
Diseases associated with anti-14-3-3 epsilon antibody
Organs/Tissues associated with anti-14-3-3 epsilon antibody
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