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anti-YWHAB antibody :: Rabbit 14-3-3 protein beta/alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS715448
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3 protein beta/alpha (YWHAB), Polyclonal Antibody

 Also Known As   

Rabbit anti-human 14-3-3 protein beta/alpha polyclonal Antibody, HRP conjugated

 Product Synonym Names    Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1; 14-3-3 protein beta/alpha; N-terminally processed
 Product Gene Name   

anti-YWHAB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601289
 3D Structure    ModBase 3D Structure for P31946
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    HRP
 Immunogen    Recombinant human 14-3-3 protein beta/alpha protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17288 / sc-13959 / sc-629 / sc-628
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-YWHAB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-YWHAB antibody

   Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf 1 kinase activity and phosphorylation amoung many other functions.
 Applications Tested/Suitable for anti-YWHAB antibody   

ELISA (EIA)

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 Western Blot (WB) of anti-YWHAB antibody    All lanes: 14-3-3 protein beta/alpha antibody at 2 ug/ml Lane 1: 293T whole cell lysate Lane 2: EC109 whole cell lysate SecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilution Predicted band size: 27 kDa Observed band size:27 kDa Immunohistochemistry
anti-YWHAB antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-YWHAB antibody    Immunohistochemistry of paraffin-embeded human kidney at dilution of 1:50
anti-YWHAB antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for YWHAB. It may not necessarily be applicable to this product.
 NCBI GI #    4507949
 NCBI GeneID    7529
 NCBI Accession #    NP_003395.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003404.4 [Other Products]
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 UniProt Primary Accession #    P31946 [Other Products]
 UniProt Secondary Accession #    A8K9K2; E1P616 [Other Products]
 UniProt Related Accession #    P31946 [Other Products]
 Molecular Weight    27,850 Da [Similar Products]
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 NCBI Official Full Name    14-3-3 protein beta/alpha
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
 NCBI Official Symbol    YWHAB [Similar Products]
 NCBI Official Synonym Symbols   
HS1; GW128; YWHAA; KCIP-1; HEL-S-1
[Similar Products]
 NCBI Protein Information    14-3-3 protein beta/alpha
 UniProt Protein Name    14-3-3 protein beta/alpha
 UniProt Synonym Protein Names   
Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
 Protein Family    14-3-3 protein
 UniProt Gene Name    YWHAB [Similar Products]
 UniProt Synonym Gene Names    KCIP-1 [Similar Products]
 UniProt Entry Name    1433B_HUMAN
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 NCBI Summary for YWHAB    This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for YWHAB    14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; focal adhesion; melanosome; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; transcriptional repressor complex

Molecular Function: enzyme binding; histone deacetylase binding; phosphoprotein binding; phosphoserine binding; protein binding; protein C-terminus binding; protein complex binding; protein domain specific binding; transcription corepressor activity

Biological Process: activation of MAPKK activity; apoptosis; axon guidance; cytoplasmic sequestering of protein; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; gene expression; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of protein amino acid dephosphorylation; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of catalytic activity; programmed cell death; protein heterooligomerization; protein targeting; Ras protein signal transduction; regulation of mRNA stability; small GTPase mediated signal transduction; transcription initiation from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway; viral reproduction
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 Research Articles on YWHAB    1. These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-YWHAB antibodyPathways associated with anti-YWHAB antibody
 Reference Product  PubMed Publications
 CDC25B antibody  >3 publications with YWHAB and CDC25B
 CDC25C antibody  >2 publications with YWHAB and CDC25C
 MAP2K1 antibody  >1 publications with YWHAB and MAP2K1
 FOXO3 antibody  >1 publications with YWHAB and FOXO3
 HDAC4 antibody  >1 publications with YWHAB and HDAC4
 TSC2 antibody  >1 publications with YWHAB and TSC2
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Butyrate Response Factor 1 (BRF1) Binds And Destabilizes MRNA Pathway antibodies  Butyrate Response Factor 1 (BRF1) Binds And Destabilizes MRNA Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-YWHAB antibodyOrgans/Tissues associated with anti-YWHAB antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >16 publications with YWHAB and Nervous System Diseases
 Carcinoma Antibodies  >7 publications with YWHAB and Carcinoma
 Liver Diseases Antibodies  >4 publications with YWHAB and Liver Diseases
 Inflammation Antibodies  >4 publications with YWHAB and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with YWHAB and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with YWHAB and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with YWHAB and Liver Neoplasms
 Seizures Antibodies  >2 publications with YWHAB and Seizures
 Neurodegenerative Diseases Antibodies  >2 publications with YWHAB and Neurodegenerative Diseases
 Neoplasm Metastasis Antibodies  >2 publications with YWHAB and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with YWHAB and Brain
 Blood Antibodies  >8 publications with YWHAB and Blood
 Liver Antibodies  >6 publications with YWHAB and Liver
 Vascular Antibodies  >5 publications with YWHAB and Vascular
 Muscle Antibodies  >5 publications with YWHAB and Muscle
 Kidney Antibodies  >3 publications with YWHAB and Kidney
 Nerve Antibodies  >3 publications with YWHAB and Nerve
 Prostate Antibodies  >2 publications with YWHAB and Prostate
 Lung Antibodies  >2 publications with YWHAB and Lung
 Ganglia Antibodies  >2 publications with YWHAB and Ganglia
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