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anti-YWHAH antibody :: Rabbit anti-Human 14-3-3 protein eta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1490959
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3 protein eta (YWHAH), Polyclonal Antibody

 Also Known As   

Rabbit anti-Human 14-3-3 protein eta polyclonal Antibody, Biotin conjugated

 Product Synonym Names    Protein AS1; YWHAH; YWHA1
 Product Gene Name   

anti-YWHAH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    113508
 3D Structure    ModBase 3D Structure for Q04917
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant Human 14-3-3 protein eta protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17286 / sc-17287
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-YWHAH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-YWHAH antibody

   Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
 Applications Tested/Suitable for anti-YWHAH antibody   

ELISA (EIA), Immunohistochemistry (IHC)

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 Immunohistochemistry (IHC) of anti-YWHAH antibody    Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100
anti-YWHAH antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for YWHAH. It may not necessarily be applicable to this product.
 NCBI GI #    4507951
 NCBI GeneID    7533
 NCBI Accession #    NP_003396.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003405.3 [Other Products]
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 UniProt Primary Accession #    Q04917 [Other Products]
 UniProt Related Accession #    Q04917 [Other Products]
 Molecular Weight    28,219 Da [Similar Products]
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 NCBI Official Full Name    14-3-3 protein eta
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
 NCBI Official Symbol    YWHAH [Similar Products]
 NCBI Official Synonym Symbols   
YWHA1
[Similar Products]
 NCBI Protein Information    14-3-3 protein eta
 UniProt Protein Name    14-3-3 protein eta
 UniProt Synonym Protein Names   
Protein AS1
 Protein Family    14-3-3 protein
 UniProt Gene Name    YWHAH [Similar Products]
 UniProt Synonym Gene Names    YWHA1 [Similar Products]
 UniProt Entry Name    1433F_HUMAN
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 NCBI Summary for YWHAH    This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
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 UniProt Comments for YWHAH    14-3-3 eta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; mitochondrion; plasma membrane

Molecular Function: actin binding; enzyme binding; glucocorticoid receptor binding; insulin-like growth factor receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; sodium channel regulator activity

Biological Process: apoptosis; gene expression; glucocorticoid catabolic process; glucocorticoid receptor signaling pathway; intracellular protein transport; negative regulation of dendrite morphogenesis; positive regulation of transcription, DNA-dependent; programmed cell death; regulation of neuron differentiation; regulation of sodium ion transport; regulation of synaptic plasticity; small GTPase mediated signal transduction; substantia nigra development; transcription initiation from RNA polymerase II promoter
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 Research Articles on YWHAH    1. Extracellular 14-3-3eta activates key signalling cascades and induces factors associated with the pathogenesis of rheumatoid arthritis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-YWHAH antibodyPathways associated with anti-YWHAH antibody
 Reference Product  PubMed Publications
 YWHAE antibody  >2 publications with YWHAH and YWHAE
 FOXO3 antibody  >1 publications with YWHAH and FOXO3
 CDC25C antibody  >1 publications with YWHAH and CDC25C
 CDC25B antibody  >1 publications with YWHAH and CDC25B
 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-YWHAH antibodyOrgans/Tissues associated with anti-YWHAH antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with YWHAH and Nervous System Diseases
 Brain Diseases Antibodies  >7 publications with YWHAH and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with YWHAH and Cell Transformation, Neoplastic
 Insulin Resistance Antibodies  >1 publications with YWHAH and Insulin Resistance
 Carcinoma, Hepatocellular Antibodies  >1 publications with YWHAH and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with YWHAH and Liver Diseases
 Hypertrophy Antibodies  >1 publications with YWHAH and Hypertrophy
 Liver Neoplasms Antibodies  >1 publications with YWHAH and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with YWHAH and Neoplasms, Experimental
 Hyperplasia Antibodies  >1 publications with YWHAH and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with YWHAH and Brain
 Blood Antibodies  >4 publications with YWHAH and Blood
 Bone Antibodies  >3 publications with YWHAH and Bone
 Liver Antibodies  >2 publications with YWHAH and Liver
 Lymph Antibodies  >2 publications with YWHAH and Lymph
 Bone Marrow Antibodies  >2 publications with YWHAH and Bone Marrow
 Lung Antibodies  >2 publications with YWHAH and Lung
 Prostate Antibodies  >2 publications with YWHAH and Prostate
 Lymph Node Antibodies  >2 publications with YWHAH and Lymph Node
 Heart Antibodies  >1 publications with YWHAH and Heart
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