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anti-YWHAZ antibody :: Rabbit 14-3-3 zeta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820541
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3 zeta (YWHAZ), Polyclonal Antibody

 Also Known As   

Anti-14-3-3 zeta Antibody

 Product Synonym Names    14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1
 Product Gene Name   

anti-YWHAZ antibody

[Similar Products]
 Antibody/Peptide Pairs    14-3-3 zeta peptide (MBS823141) is used for blocking the activity of 14-3-3 zeta antibody (MBS820541)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601288
 3D Structure    ModBase 3D Structure for P63104
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Bovine, Chicken, Pig, Sheep, Zebrafish
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 Specificity    Recognizes endogenous levels of 14-3-3 zeta protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human 14-3-3 zeta. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-YWHAZ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-YWHAZ antibody

   Rabbit polyclonal antibody to 14-3-3 zeta
 Applications Tested/Suitable for anti-YWHAZ antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

 Application Notes for anti-YWHAZ antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500), IP (1/10 - 1/100)
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 Western Blot (WB) of anti-YWHAZ antibody    anti-YWHAZ antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-YWHAZ antibody    Immunohistochemical analysis of 14-3-3 zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-YWHAZ antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence/Immunocytochemistry (IF/ICC) of anti-YWHAZ antibody    Immunofluorescent analysis of 14-3-3 zeta staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-YWHAZ antibody Immunofluorescence/Immunocytochemistry (IF/ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for YWHAZ. It may not necessarily be applicable to this product.
 NCBI GI #    208973238
 NCBI GeneID    7534
 NCBI Accession #    NP_001129171.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135699.1 [Other Products]
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 UniProt Primary Accession #    P63104 [Other Products]
 UniProt Secondary Accession #    P29213; P29312; Q32P43; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; A8K1N0; B7Z465 [Other Products]
 UniProt Related Accession #    P63104 [Other Products]
 Molecular Weight    19,333 Da
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 NCBI Official Full Name    14-3-3 protein zeta/delta
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
 NCBI Official Symbol    YWHAZ [Similar Products]
 NCBI Official Synonym Symbols   
HEL4; YWHAD; KCIP-1; HEL-S-3; 14-3-3-zeta
[Similar Products]
 NCBI Protein Information    14-3-3 protein zeta/delta; 14-3-3 zeta; 14-3-3 delta; phospholipase A2; epididymis luminal protein 4; epididymis secretory protein Li 3; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; 14-3-3 protein/cytosolic phospholipase A2; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
 UniProt Protein Name    14-3-3 protein zeta/delta
 UniProt Synonym Protein Names   
Protein kinase C inhibitor protein 1; KCIP-1
 Protein Family    14-3-3 protein
 UniProt Gene Name    YWHAZ [Similar Products]
 UniProt Synonym Gene Names    KCIP-1 [Similar Products]
 UniProt Entry Name    1433Z_HUMAN
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 NCBI Summary for YWHAZ    This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for YWHAZ    14-3-3 zeta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Phosphorylation apparently disrupts homodimerization.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8q23.1

Cellular Component: extracellular space; protein complex; mast cell granule; cytoplasmic vesicle membrane; focal adhesion; mitochondrion; leading edge; postsynaptic density; cytosol; nucleoplasm; perinuclear region of cytoplasm; cytoplasm; melanosome; nucleus

Molecular Function: identical protein binding; protein domain specific binding; protein binding; protein complex binding; protein kinase binding; transcription factor binding

Biological Process: response to drug; platelet activation; histamine secretion by mast cell; apoptosis; establishment of Golgi localization; gene expression; blood coagulation; signal transduction; protein targeting to mitochondrion; negative regulation of apoptosis
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 Research Articles on YWHAZ    1. 14-3-3zeta regulates nuclear trafficking of PP1alpha in mammalian cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-YWHAZ antibodyDiseases associated with anti-YWHAZ antibody
 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >20 publications with YWHAZ and Carcinoma
 Nervous System Diseases Antibodies  >13 publications with YWHAZ and Nervous System Diseases
 Disease Models, Animal Antibodies  >11 publications with YWHAZ and Disease Models, Animal
 Breast Neoplasms Antibodies  >9 publications with YWHAZ and Breast Neoplasms
 Inflammation Antibodies  >8 publications with YWHAZ and Inflammation
 Skin Diseases Antibodies  >8 publications with YWHAZ and Skin Diseases
 Adenocarcinoma Antibodies  >7 publications with YWHAZ and Adenocarcinoma
 Liver Diseases Antibodies  >7 publications with YWHAZ and Liver Diseases
 Heart Diseases Antibodies  >6 publications with YWHAZ and Heart Diseases
 Neoplasms, Experimental Antibodies  >6 publications with YWHAZ and Neoplasms, Experimental
Organs/Tissues associated with anti-YWHAZ antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >25 publications with YWHAZ and Brain
 Blood Antibodies  >23 publications with YWHAZ and Blood
 Liver Antibodies  >21 publications with YWHAZ and Liver
 Muscle Antibodies  >13 publications with YWHAZ and Muscle
 Lung Antibodies  >11 publications with YWHAZ and Lung
 Heart Antibodies  >11 publications with YWHAZ and Heart
 Kidney Antibodies  >8 publications with YWHAZ and Kidney
 Placenta Antibodies  >6 publications with YWHAZ and Placenta
 Adipose Tissue Antibodies  >6 publications with YWHAZ and Adipose Tissue
 Connective Tissue Antibodies  >6 publications with YWHAZ and Connective Tissue
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