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anti-14-3-3 PROTEIN antibody :: Sheep 14-3-3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221102 anti-14-3-3 PROTEIN antibody
Unit / Price
1 mL  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3 (14-3-3 PROTEIN), Polyclonal Antibody

 Also Known As   

SHEEP ANTI HUMAN 14-3-3 PROTEIN

 Product Gene Name   

anti-14-3-3 PROTEIN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609009
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
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 Specificity    This item recognises the lower molecular weight subunit (26 kD) of protein 14-3-3.The 14-3-3 family consists of 30kD proteins that are involved in multiple cellular processes including protein kinase signalling pathways, regulation of cell cycle progression, transcription and intracellular trafficking. Protein interactions with 14-3-3 show distinct preferences for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein.
 Form/Format    Purified
Purified Ig - liquid
 Concentration    Ig concentration 2.5 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    Native, purified from pathogen-free normal human brain.
Buffer Solution
 Antiserum Preparation    Antisera to 14-3-3 were raised by repeated immunisations of sheep with highly purified antigen.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-14-3-3 PROTEIN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-14-3-3 PROTEIN antibody

   MBS221102 recognises the lower molecular weight subunit (26 kD) of protein 14-3-3. The 14-3-3 family consists of 30kD proteins that are involved in multiple cellular processes including protein kinase signalling pathways, regulation of cell cycle progression, transcription and intracellular trafficking. Protein interactions with 14-3-3 show distinct preferences for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein.
 Applications Tested/Suitable for anti-14-3-3 PROTEIN antibody   

Western Blot (WB)

 Application Notes for anti-14-3-3 PROTEIN antibody    Western Blotting: Minimum Dilution: 1/10; Maximum Dilution: 1/50
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NCBI/Uniprot data below describe general gene information for 14-3-3 PROTEIN. It may not necessarily be applicable to this product.
 NCBI GI #    5803227
 NCBI GeneID    10971
 NCBI Accession #    NP_006817.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006826.3 [Other Products]
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 UniProt Secondary Accession #    Q567U5; Q5TZU8; Q9UP48; D6W4Z5 [Other Products]
 UniProt Related Accession #    P27348 [Other Products]
 Molecular Weight    27,764 Da
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 NCBI Official Full Name    14-3-3 protein theta
 NCBI Official Synonym Full Names    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
 NCBI Official Symbol    YWHAQ [Similar Products]
 NCBI Official Synonym Symbols   
1C5; HS1; 14-3-3
[Similar Products]
 NCBI Protein Information    14-3-3 protein theta; 14-3-3 protein T-cell; 14-3-3 protein tau; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
 UniProt Protein Name    14-3-3 protein theta
 UniProt Synonym Protein Names   
14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1
 Protein Family    14-3-3 protein
 UniProt Gene Name    YWHAQ [Similar Products]
 UniProt Entry Name    1433T_HUMAN
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 NCBI Summary for 14-3-3 PROTEIN    This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for 14-3-3 PROTEIN    14-3-3 theta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: focal adhesion; cytoplasmic vesicle membrane; membrane; cytoplasm; cytosol

Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding

Biological Process: substantia nigra development; apoptosis; small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; protein targeting
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 Research Articles on 14-3-3 PROTEIN    1. CCL20 and 14-3-3 zeta are molecules that play a putative role during tumorgenesis in pancreas, and may therefore be new parameters for histological diagnosis and discrimination between pancreatic neoplasms and chronic pancreatitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-14-3-3 PROTEIN antibodyPathways associated with anti-14-3-3 PROTEIN antibody
 Reference Product  PubMed Publications
 YWHAB antibody  >1 publications with 14-3-3 PROTEIN and YWHAB
 YWHAH antibody  >1 publications with 14-3-3 PROTEIN and YWHAH
 BAD antibody  >1 publications with 14-3-3 PROTEIN and BAD
 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
Diseases associated with anti-14-3-3 PROTEIN antibodyOrgans/Tissues associated with anti-14-3-3 PROTEIN antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1 publications with 14-3-3 PROTEIN and Adenocarcinoma
 Breast Neoplasms Antibodies  >1 publications with 14-3-3 PROTEIN and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >4 publications with 14-3-3 PROTEIN and Muscle
 Brain Antibodies  >4 publications with 14-3-3 PROTEIN and Brain
 Nerve Antibodies  >3 publications with 14-3-3 PROTEIN and Nerve
 Heart Antibodies  >2 publications with 14-3-3 PROTEIN and Heart
 Prostate Antibodies  >2 publications with 14-3-3 PROTEIN and Prostate
 Blood Antibodies  >2 publications with 14-3-3 PROTEIN and Blood
 Embryonic Tissue Antibodies  >2 publications with 14-3-3 PROTEIN and Embryonic Tissue
 Liver Antibodies  >1 publications with 14-3-3 PROTEIN and Liver
 Kidney Antibodies  >1 publications with 14-3-3 PROTEIN and Kidney
 Placenta Antibodies  >1 publications with 14-3-3 PROTEIN and Placenta
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