NP_001034219.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,523 Da
NCBI Official Full Name
arachidonate 15-lipoxygenase B isoform a
NCBI Official Synonym Full Names
arachidonate 15-lipoxygenase, type B
NCBI Official Synonym Symbols
NCBI Protein Information
arachidonate 15-lipoxygenase B
UniProt Protein Name
Arachidonate 15-lipoxygenase B
UniProt Synonym Protein Names
15-lipoxygenase 2; 15-LOX-2; Arachidonate 15-lipoxygenase type II; Linoleate 13-lipoxygenase 15-LOb (EC:1.13.11.-)
UniProt Synonym Gene Names
UniProt Entry Name
LX15B_HUMAN
NCBI Summary for ALOX15B
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for ALOX15B
ALOX15B: Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized. Belongs to the lipoxygenase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Oxidoreductase; Cell cycle regulation; Lipid Metabolism - arachidonic acid; Apoptosis; EC 1.13.11.33
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoplasm; cytoskeleton; cytosol; extrinsic to membrane; intracellular; membrane; nucleus; plasma membrane
Molecular Function: arachidonate 15-lipoxygenase activity; calcium ion binding; iron ion binding; lipid binding; lipoxygenase activity
Biological Process: apoptosis; arachidonic acid metabolic process; hepoxilin biosynthetic process; linoleic acid metabolic process; lipid metabolic process; lipoxygenase pathway; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of growth; positive regulation of keratinocyte differentiation; prostate gland development; regulation of epithelial cell differentiation
Research Articles on ALOX15B
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Pathways associated with anti-ALOX15B antibody
Diseases associated with anti-ALOX15B antibody
Organs/Tissues associated with anti-ALOX15B antibody
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