NP_062631.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,127 Da
NCBI Official Full Name
very-long-chain 3-oxoacyl-CoA reductase
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 12
NCBI Official Synonym Symbols
Kik1; KIK-I; AI172963; 2610510O05Rik [Similar Products]
NCBI Protein Information
very-long-chain 3-oxoacyl-CoA reductase
UniProt Protein Name
Very-long-chain 3-oxoacyl-CoA reductase
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 12
UniProt Synonym Gene Names
UniProt Comments for HSD17b12
HSD17B12: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Protein type: EC 1.1.1.62; Lipid Metabolism - androgen and estrogen; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: 2|2 E1
Cellular Component: endoplasmic reticulum; integral component of membrane; membrane; proteinaceous extracellular matrix
Molecular Function: collagen binding; estradiol 17-beta-dehydrogenase activity; fibronectin binding; heparin binding; long-chain-3-hydroxyacyl-CoA dehydrogenase activity; oxidoreductase activity
Biological Process: extracellular matrix organization; lipid metabolic process; steroid biosynthetic process
Research Articles on HSD17b12
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Pathways associated with anti-HSD17b12 antibody
Diseases associated with anti-HSD17b12 antibody
Organs/Tissues associated with anti-HSD17b12 antibody
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