NP_066956.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
2-5A-dependent ribonuclease
NCBI Official Synonym Full Names
ribonuclease L
NCBI Official Synonym Symbols
NCBI Protein Information
2-5A-dependent ribonuclease
UniProt Protein Name
2-5A-dependent ribonuclease
UniProt Synonym Protein Names
Ribonuclease 4; Ribonuclease L; RNase L
UniProt Synonym Gene Names
UniProt Entry Name
RN5A_HUMAN
NCBI Summary for RNASEL
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]
UniProt Comments for RNASEL
RNASEL: a multifunctional enzyme that possesses protein kinase and endoribonuclease activity, Mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover.
Protein type: Kinase, protein; Protein kinase, Other; EC 3.1.26.-; Ribonuclease; Protein kinase, Ser/Thr (non-receptor); Other group; Other-Unique family
Chromosomal Location of Human Ortholog: 1q25
Cellular Component: cytosol; mitochondrial matrix; nuclear matrix
Molecular Function: ATP binding; endoribonuclease activity; metal ion binding; protein binding; protein kinase activity; ribonucleoprotein binding; RNA binding; rRNA binding
Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; fat cell differentiation; mRNA processing; negative regulation of viral genome replication; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of mRNA stability; rRNA processing; transmembrane transport
Disease: Prostate Cancer, Hereditary, 1
Research Articles on RNASEL
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Products associated with anti-RNASEL antibody
Pathways associated with anti-RNASEL antibody
Diseases associated with anti-RNASEL antibody
Organs/Tissues associated with anti-RNASEL antibody
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