NP_005310.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,365 Da
NCBI Official Full Name
histone H1.2
NCBI Official Synonym Full Names
histone cluster 1 H1 family member c
NCBI Protein Information
histone H1.2
UniProt Protein Name
Histone H1.2
UniProt Synonym Protein Names
Histone H1c; Histone H1d; Histone H1s-1
UniProt Synonym Gene Names
NCBI Summary for HIST1H1C
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
UniProt Comments for HIST1H1C
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation ().
Research Articles on HIST1H1C
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Products associated with anti-HIST1H1C antibody
Pathways associated with anti-HIST1H1C antibody
Diseases associated with anti-HIST1H1C antibody
Organs/Tissues associated with anti-HIST1H1C antibody
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