NP_002805.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,137 Da
NCBI Official Full Name
26S proteasome non-ATPase regulatory subunit 10 isoform 1
NCBI Official Synonym Full Names
proteasome 26S subunit, non-ATPase 10
NCBI Protein Information
26S proteasome non-ATPase regulatory subunit 10
UniProt Protein Name
26S proteasome non-ATPase regulatory subunit 10
UniProt Synonym Protein Names
26S proteasome regulatory subunit p28; Gankyrin; p28(GANK)
UniProt Entry Name
PSD10_HUMAN
NCBI Summary for PSMD10
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]
UniProt Comments for PSMD10
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Research Articles on PSMD10
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Products associated with anti-PSMD10 antibody
Pathways associated with anti-PSMD10 antibody
Diseases associated with anti-PSMD10 antibody
Disease Name |
Pubmed Publications |
Carcinoma, Hepatocellular Antibodies |
>35 publications with PSMD10 and Carcinoma, Hepatocellular |
Liver Diseases Antibodies |
>33 publications with PSMD10 and Liver Diseases |
Liver Neoplasms Antibodies |
>31 publications with PSMD10 and Liver Neoplasms |
Neoplasm Metastasis Antibodies |
>17 publications with PSMD10 and Neoplasm Metastasis |
Disease Models, Animal Antibodies |
>9 publications with PSMD10 and Disease Models, Animal |
Neoplasms, Experimental Antibodies |
>8 publications with PSMD10 and Neoplasms, Experimental |
Cell Transformation, Neoplastic Antibodies |
>7 publications with PSMD10 and Cell Transformation, Neoplastic |
Liver Neoplasms, Experimental Antibodies |
>6 publications with PSMD10 and Liver Neoplasms, Experimental |
Lung Neoplasms Antibodies |
>5 publications with PSMD10 and Lung Neoplasms |
Fibrosis Antibodies |
>4 publications with PSMD10 and Fibrosis |
Organs/Tissues associated with anti-PSMD10 antibody
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