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anti-OXCT1 antibody :: Rabbit 3-oxoacid CoA transferase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716611 anti-OXCT1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3-oxoacid CoA transferase 1 (OXCT1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human 3-oxoacid CoA transferase 1 polyclonal Antibody

 Product Synonym Names    3-oxoacid CoA transferase 1; OXCT1; OXCT; SCOT
 Product Gene Name   

anti-OXCT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601424
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human SCOT
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-160776 / sc-133988
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-OXCT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-OXCT1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for OXCT1. It may not necessarily be applicable to this product.
 NCBI GI #    14290472
 NCBI GeneID    5019
 NCBI Accession #    AAH09001.1 [Other Products]
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 UniProt Secondary Accession #    B2R5V2; B7Z528 [Other Products]
 UniProt Related Accession #    P55809 [Other Products]
 Molecular Weight    13,358 Da [Similar Products]
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 NCBI Official Full Name    3-oxoacid CoA transferase 1
 NCBI Official Synonym Full Names    3-oxoacid CoA transferase 1
 NCBI Official Symbol    OXCT1 [Similar Products]
 NCBI Official Synonym Symbols   
OXCT; SCOT
[Similar Products]
 NCBI Protein Information    succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; SCOT-s; 3-oxoacid CoA-transferase 1; 3-oxoacid-CoA transferase 1; succinyl CoA:3-oxoacid CoA transferase; succinyl-CoA:3-ketoacid-CoA transferase; somatic-type succinyl CoA:3-oxoacid CoA-transferase; somatic-type succinyl-CoA:3-oxoacid CoA-transferase; somatic-type succinyl-CoA:3-oxoacid-CoA-transferase; succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial
 UniProt Protein Name    Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
 UniProt Synonym Protein Names   
3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s
 Protein Family    Succinyl-CoA:3-ketoacid coenzyme A transferase
 UniProt Gene Name    OXCT1 [Similar Products]
 UniProt Synonym Gene Names    OXCT; SCOT; SCOT-s [Similar Products]
 UniProt Entry Name    SCOT1_HUMAN
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 NCBI Summary for OXCT1    This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for OXCT1    OXCT1: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. Defects in OXCT1 are a cause of succinyl-CoA-3-ketoacid- CoA transferase deficiency (SCOTD). A disorder of ketone body metabolism, characterized by episodic ketoacidosis. Patients are usually asymptomatic between episodes. Belongs to the 3-oxoacid CoA-transferase family.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; Transferase; Lipid Metabolism - synthesis and degradation of ketone bodies; EC 2.8.3.5; Carbohydrate Metabolism - butanoate

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: protein homodimerization activity; 3-oxoacid CoA-transferase activity

Biological Process: response to drug; response to starvation; response to ethanol; heart development; ketone body catabolic process; response to hormone stimulus; ketone catabolic process; cellular lipid metabolic process; brain development; ketone body metabolic process; response to activity; response to nutrient

Disease: Succinyl-coa:3-oxoacid Coa Transferase Deficiency
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 Research Articles on OXCT1    1. Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-OXCT1 antibodyPathways associated with anti-OXCT1 antibody
 Reference Product  PubMed Publications
 ACAT1 antibody  >5 publications with OXCT1 and ACAT1
 BDH1 antibody  >4 publications with OXCT1 and BDH1
 HMGCS2 antibody  >3 publications with OXCT1 and HMGCS2
 EHHADH antibody  >1 publications with OXCT1 and EHHADH
 BDH2 antibody  >1 publications with OXCT1 and BDH2
 HMGCL antibody  >1 publications with OXCT1 and HMGCL
 Products by Pathway  Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Ketone Body Metabolism Pathway antibodies  Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Synthesis And Degradation Of Ketone Bodies Pathway antibodies  Synthesis And Degradation Of Ketone Bodies Pathway Diagram
 Synthesis And Degradation Of Ketone Bodies Pathway antibodies  Synthesis And Degradation Of Ketone Bodies Pathway Diagram
 Synthesis And Degradation Of Ketone Bodies Pathway antibodies  Synthesis And Degradation Of Ketone Bodies Pathway Diagram
 Utilization Of Ketone Bodies Pathway antibodies  Utilization Of Ketone Bodies Pathway Diagram
Diseases associated with anti-OXCT1 antibodyOrgans/Tissues associated with anti-OXCT1 antibody
 Disease Name  Pubmed Publications
 Succinyl-CoA:3-oxoacid CoA transferase deficiency Antibodies  >3 publications with OXCT1 and Succinyl-CoA:3-oxoacid CoA transferase deficiency
 Fatty Liver Antibodies  >2 publications with OXCT1 and Fatty Liver
 Breast Neoplasms Antibodies  >2 publications with OXCT1 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with OXCT1 and Prostatic Neoplasms
 Movement Disorders Antibodies  >1 publications with OXCT1 and Movement Disorders
 Brain Diseases Antibodies  >1 publications with OXCT1 and Brain Diseases
 Heart Failure Antibodies  >1 publications with OXCT1 and Heart Failure
 Cognition Disorders Antibodies  >1 publications with OXCT1 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with OXCT1 and Blood
 Muscle Antibodies  >6 publications with OXCT1 and Muscle
 Heart Antibodies  >4 publications with OXCT1 and Heart
 Brain Antibodies  >3 publications with OXCT1 and Brain
 Liver Antibodies  >2 publications with OXCT1 and Liver
 Prostate Antibodies  >1 publications with OXCT1 and Prostate
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