NP_001159477.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,235 Da
NCBI Official Full Name
protein 4.1 isoform 1
NCBI Official Synonym Full Names
erythrocyte membrane protein band 4.1
NCBI Protein Information
protein 4.1
UniProt Protein Name
Protein 4.1
UniProt Synonym Protein Names
4.1R; Band 4.1; EPB4.1
UniProt Synonym Gene Names
NCBI Summary for 4.1R
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for 4.1R
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).
Research Articles on 4.1R
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Products associated with anti-4.1R antibody
Pathways associated with anti-4.1R antibody
Diseases associated with anti-4.1R antibody
Organs/Tissues associated with anti-4.1R antibody
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