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anti-HPD antibody :: Rabbit anti-Human 4-hydroxyphenylpyruvate dioxygenase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1489913 anti-HPD antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4-hydroxyphenylpyruvate dioxygenase (HPD), Polyclonal Antibody

 Also Known As   

Rabbit anti-human 4-hydroxyphenylpyruvate dioxygenase polyclonal Antibody, Biotin conjugated

 Product Synonym Names    4-hydroxyphenylpyruvic acid oxidase
 Product Gene Name   

anti-HPD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    140350
 3D Structure    ModBase 3D Structure for P32754
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant human 4-hydroxyphenylpyruvate dioxygenase protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-69282 / sc-69284 / sc-98596
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HPD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HPD antibody

   Key enzyme in the degradation of tyrosine.
 Applications Tested/Suitable for anti-HPD antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for HPD. It may not necessarily be applicable to this product.
 NCBI GI #    285002264
 NCBI GeneID    3242
 NCBI Accession #    NP_001165464.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001171993.1 [Other Products]
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 UniProt Primary Accession #    P32754 [Other Products]
 UniProt Secondary Accession #    Q13234; A8K461; B3KQ63 [Other Products]
 UniProt Related Accession #    P32754 [Other Products]
 Molecular Weight    40,497 Da [Similar Products]
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 NCBI Official Full Name    4-hydroxyphenylpyruvate dioxygenase isoform 2
 NCBI Official Synonym Full Names    4-hydroxyphenylpyruvate dioxygenase
 NCBI Official Symbol    HPD [Similar Products]
 NCBI Official Synonym Symbols   
PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE
[Similar Products]
 NCBI Protein Information    4-hydroxyphenylpyruvate dioxygenase
 UniProt Protein Name    4-hydroxyphenylpyruvate dioxygenase
 UniProt Synonym Protein Names   
4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase
 Protein Family    4-hydroxyphenylpyruvate dioxygenase
 UniProt Gene Name    HPD [Similar Products]
 UniProt Synonym Gene Names    PPD; 4HPPD; HPD; HPPDase [Similar Products]
 UniProt Entry Name    HPPD_HUMAN
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 NCBI Summary for HPD    The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
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 UniProt Comments for HPD    HPD: Key enzyme in the degradation of tyrosine. Defects in HPD are the cause of tyrosinemia type 3 (TYRO3). TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK). HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Belongs to the 4HPPD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.13.11.27; Oxidoreductase; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Amino Acid Metabolism - phenylalanine

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cytosol

Molecular Function: 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding

Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process

Disease: Hawkinsinuria; Tyrosinemia, Type Iii
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 Research Articles on HPD    1. Glutamine375 has a critical role for 4-HPPD in orientating the tail and ensuring the conformation of the terminal alpha-helix of the enzyme to maintain the integrity of the active site for biocatalysis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HPD antibodyPathways associated with anti-HPD antibody
 Reference Product  PubMed Publications
 FAH antibody  >8 publications with HPD and FAH
 PAH antibody  >6 publications with HPD and PAH
 HGD antibody  >2 publications with HPD and HGD
 TAT antibody  >1 publications with HPD and TAT
 Products by Pathway  Pathway Diagram
 Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway antibodies  Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway Diagram
 L-phenylalanine Degradation IV (mammalian, Via Side Chain) Pathway antibodies  L-phenylalanine Degradation IV (mammalian, Via Side Chain) Pathway Diagram
 L-tyrosine Degradation I Pathway antibodies  L-tyrosine Degradation I Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Phenylalanine And Tyrosine Catabolism Pathway antibodies  Phenylalanine And Tyrosine Catabolism Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Tyrosine Degradation, Tyrosine => Homogentisate Pathway antibodies  Tyrosine Degradation, Tyrosine => Homogentisate Pathway Diagram
Diseases associated with anti-HPD antibodyOrgans/Tissues associated with anti-HPD antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >94 publications with HPD and Brain Diseases
 Necrosis Antibodies  >84 publications with HPD and Necrosis
 Lung Neoplasms Antibodies  >62 publications with HPD and Lung Neoplasms
 Liver Neoplasms Antibodies  >57 publications with HPD and Liver Neoplasms
 Lung Diseases Antibodies  >56 publications with HPD and Lung Diseases
 Urinary Bladder Neoplasms Antibodies  >49 publications with HPD and Urinary Bladder Neoplasms
 Liver Diseases Antibodies  >43 publications with HPD and Liver Diseases
 Kidney Diseases Antibodies  >37 publications with HPD and Kidney Diseases
 Liver Neoplasms, Experimental Antibodies  >23 publications with HPD and Liver Neoplasms, Experimental
 Heart Diseases Antibodies  >22 publications with HPD and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >234 publications with HPD and Brain
 Liver Antibodies  >136 publications with HPD and Liver
 Lung Antibodies  >74 publications with HPD and Lung
 Kidney Antibodies  >73 publications with HPD and Kidney
 Eye Antibodies  >33 publications with HPD and Eye
 Lymph Antibodies  >21 publications with HPD and Lymph
 Testis Antibodies  >9 publications with HPD and Testis
 Cervix Antibodies  >6 publications with HPD and Cervix
 Mammary Gland Antibodies  >1 publications with HPD and Mammary Gland
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