Q13541
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
4E-binding protein 1
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4E binding protein 1
NCBI Official Synonym Symbols
BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316 [Similar Products]
NCBI Protein Information
eukaryotic translation initiation factor 4E-binding protein 1; OTTHUMP00000225572; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1
UniProt Protein Name
Eukaryotic translation initiation factor 4E-binding protein 1
UniProt Synonym Protein Names
Phosphorylated heat- and acid-stable protein regulated by insulin 1
UniProt Entry Name
4EBP1_HUMAN
NCBI Summary for EIF4EBP1
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq]
UniProt Comments for EIF4EBP1
4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 8p12
Cellular Component: nucleoplasm; protein complex; cytoplasm; cytosol
Molecular Function: protein binding; translation repressor activity; eukaryotic initiation factor 4E binding
Biological Process: negative regulation of translational initiation; response to ethanol; cellular protein metabolic process; TOR signaling pathway; translation; insulin receptor signaling pathway; translational initiation; gene expression; positive regulation of mitotic cell cycle; negative regulation of protein complex assembly; G1/S transition of mitotic cell cycle; lung development
Research Articles on EIF4EBP1
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Products associated with anti-EIF4EBP1 antibody
Pathways associated with anti-EIF4EBP1 antibody
Diseases associated with anti-EIF4EBP1 antibody
Organs/Tissues associated with anti-EIF4EBP1 antibody
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