NP_001269786.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,818 Da
NCBI Official Full Name
5'-3' exoribonuclease 1 isoform c
NCBI Official Synonym Full Names
5'-3' exoribonuclease 1
NCBI Official Synonym Symbols
NCBI Protein Information
5'-3' exoribonuclease 1
UniProt Protein Name
5'-3' exoribonuclease 1
UniProt Synonym Protein Names
Strand-exchange protein 1 homolog
UniProt Synonym Gene Names
NCBI Summary for XRN1
This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Comments for XRN1
XRN1: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). Belongs to the 5'-3' exonuclease family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.11.-; RNA-binding; Ribonuclease; Tumor suppressor
Chromosomal Location of Human Ortholog: 3q23
Cellular Component: cell soma; cytosol; dendrite; membrane; nucleus; P-body; plasma membrane; synapse
Molecular Function: 5'-3' exoribonuclease activity; G-quadruplex DNA binding; protein binding; RNA binding; telomerase RNA binding
Biological Process: cellular response to cycloheximide; negative regulation of telomere maintenance via telomerase; negative regulation of translation; nuclear mRNA surveillance; nuclear-transcribed mRNA catabolic process; regulation of mRNA stability; response to testosterone stimulus; RNA phosphodiester bond hydrolysis, exonucleolytic; rRNA catabolic process
Research Articles on XRN1
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Products associated with anti-XRN1 antibody
Pathways associated with anti-XRN1 antibody
Diseases associated with anti-XRN1 antibody
Organs/Tissues associated with anti-XRN1 antibody
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