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anti-5-HT-2A antibody :: Rabbit anti-Human 5-HT-2A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS859965
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-HT-2A, Polyclonal Antibody

 Also Known As   

5-HT-2A Antibody

 Product Synonym Names    5-hydroxytryptamine receptor 2A; 5-HT-2A; Serotonin receptor 2A; 5-HT-2; HTR2A
 Product Gene Name   

anti-5-HT-2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    182135
 3D Structure    ModBase 3D Structure for P28223
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    5-HT-2A antibody detects endogenous levels of total 5-HT-2A protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human 5-HT-2A.
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-5-HT-2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-5-HT-2A antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-5-HT-2A antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-5-HT-2A antibody    IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:5000
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 Testing Data of anti-5-HT-2A antibody    anti-5-HT-2A antibody Testing Data image
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 Testing Data #2 of anti-5-HT-2A antibody    Peptide - +
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-2A antibody.
Immunofluorescence analysis of A549 cells, using 5-HT-2A antibody.
anti-5-HT-2A antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for 5-HT-2A. It may not necessarily be applicable to this product.
 NCBI GI #    10835175
 NCBI GeneID    3356
 NCBI Accession #    NP_000612.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000621.4 [Other Products]
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 UniProt Primary Accession #    P28223 [Other Products]
 UniProt Secondary Accession #    Q5T8C0; B2RAC5; B4DZ79; F5GWE8 [Other Products]
 UniProt Related Accession #    P28223 [Other Products]
 Molecular Weight    43,940 Da
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 NCBI Official Full Name    5-hydroxytryptamine receptor 2A isoform 1
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
 NCBI Official Symbol    HTR2A [Similar Products]
 NCBI Official Synonym Symbols   
HTR2; 5-HT2A
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor
 UniProt Protein Name    5-hydroxytryptamine receptor 2A
 UniProt Synonym Protein Names   
Serotonin receptor 2A
 UniProt Gene Name    HTR2A [Similar Products]
 UniProt Synonym Gene Names    HTR2; 5-HT-2; 5-HT-2A [Similar Products]
 UniProt Entry Name    5HT2A_HUMAN
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 NCBI Summary for 5-HT-2A    This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
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 UniProt Comments for 5-HT-2A    5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: cell soma; axon; integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane; caveola; dendritic shaft; cytosol

Molecular Function: serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding

Biological Process: cell death; urinary bladder smooth muscle contraction; phosphoinositide 3-kinase cascade; negative regulation of potassium ion transport; thermoregulation; regulation of dopamine secretion; synaptic transmission; positive regulation of MAP kinase activity; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; artery smooth muscle contraction; serotonin receptor signaling pathway; regulation of behavior; aging; response to drug; serotonin receptor, phospholipase C activating pathway; regulation of hormone secretion; negative regulation of synaptic transmission, glutamatergic; sleep; positive regulation of phosphatidylinositol biosynthetic process; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation

Disease: Schizophrenia; Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Major Depressive Disorder
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Product References and Citations for anti-5-HT-2A antibody

   Saltzman A.G., Biochem. Biophys. Res. Commun. 181:1469-1478(1991).
Chen K., Brain Res. Mol. Brain Res. 14:20-26(1992).
Cook E.H. Jr., J. Neurochem. 63:465-469(1994).
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 Research Articles on 5-HT-2A    1. Data suggest that the HTR2A functional rs6311 polymorphism, which other studies have associated with differential HTR2A mRNA expression, may modulate the severity of depression symptoms in children with autism spectrum disorder.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-5-HT-2A antibodyPathways associated with anti-5-HT-2A antibody
 Reference Product  PubMed Publications
 RGS2 antibody  >5 publications with 5-HT-2A and RGS2
 CCK antibody  >2 publications with 5-HT-2A and CCK
 HCRT antibody  >1 publications with 5-HT-2A and HCRT
 GRK5 antibody  >1 publications with 5-HT-2A and GRK5
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
Diseases associated with anti-5-HT-2A antibodyOrgans/Tissues associated with anti-5-HT-2A antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >229 publications with 5-HT-2A and Mental Disorders
 Schizophrenia Antibodies  >90 publications with 5-HT-2A and Schizophrenia
 Mood Disorders Antibodies  >86 publications with 5-HT-2A and Mood Disorders
 Depressive Disorder Antibodies  >69 publications with 5-HT-2A and Depressive Disorder
 Nervous System Diseases Antibodies  >52 publications with 5-HT-2A and Nervous System Diseases
 Depressive Disorder, Major Antibodies  >52 publications with 5-HT-2A and Depressive Disorder, Major
 Bipolar Disorder Antibodies  >34 publications with 5-HT-2A and Bipolar Disorder
 Anxiety Disorders Antibodies  >32 publications with 5-HT-2A and Anxiety Disorders
 Personality Disorders Antibodies  >19 publications with 5-HT-2A and Personality Disorders
 Psychotic Disorders Antibodies  >17 publications with 5-HT-2A and Psychotic Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >106 publications with 5-HT-2A and Brain
 Eye Antibodies  >4 publications with 5-HT-2A and Eye
 Kidney Antibodies  >2 publications with 5-HT-2A and Kidney
 Embryonic Tissue Antibodies  >1 publications with 5-HT-2A and Embryonic Tissue
 Trachea Antibodies  >1 publications with 5-HT-2A and Trachea
 Thymus Antibodies  >1 publications with 5-HT-2A and Thymus
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