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anti-HTR2C antibody :: Rabbit 5-HT2C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8242072
Western Blot (WB)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-HT2C (HTR2C), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-5-HT2C Antibody

 Product Synonym Names    HTR1C; 5-hydroxytryptamine receptor 2C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
 Product Gene Name   

anti-HTR2C antibody

[Similar Products]
 Antibody/Peptide Pairs    5-HT2C peptide (MBS8243609) is used for blocking the activity of 5-HT2C antibody (MBS8242072)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    312861
 3D Structure    ModBase 3D Structure for P28335
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Dog
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 Specificity    Recognizes endogenous levels of 5-HT2C protein.
 Purity/Purification    The antibody was purified by affinity chromatography.
 Form/Format    Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% Sodium Azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human 5-HT2C. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-HTR2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HTR2C antibody

   Rabbit polyclonal antibody to 5-HT2C
 Applications Tested/Suitable for anti-HTR2C antibody   

Western Blot (WB)

 Application Notes for anti-HTR2C antibody    Western Blot: (1/500 - 1/1000)
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 Western Blot (WB) of anti-HTR2C antibody    Western blot analysis of 5-HT2C expression in SHSY5Y (A), NIH3T3 (B) whole cell lysates.
anti-HTR2C antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HTR2C. It may not necessarily be applicable to this product.
 NCBI GI #    112816
 NCBI GeneID    3358
 NCBI Accession #    P28335.1 [Other Products]
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 UniProt Primary Accession #    P28335 [Other Products]
 UniProt Secondary Accession #    Q5VUF8; Q9NP28; B1AMW4 [Other Products]
 UniProt Related Accession #    P28335 [Other Products]
 Molecular Weight    28,055 Da
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 NCBI Official Full Name    5-hydroxytryptamine receptor 2C
 NCBI Official Synonym Full Names    5-hydroxytryptamine receptor 2C
 NCBI Official Symbol    HTR2C [Similar Products]
 NCBI Official Synonym Symbols   
HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 2C
 UniProt Protein Name    5-hydroxytryptamine receptor 2C
 UniProt Synonym Protein Names   
5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
 Protein Family    5-hydroxytryptamine receptor
 UniProt Gene Name    HTR2C [Similar Products]
 UniProt Synonym Gene Names    HTR1C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-HT-1C; 5-HT1C [Similar Products]
 UniProt Entry Name    5HT2C_HUMAN
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 NCBI Summary for HTR2C    This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
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 UniProt Comments for HTR2C    5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: cytosol; integral to plasma membrane; plasma membrane

Molecular Function: 5-HT2 receptor activity; drug binding; serotonin binding; serotonin receptor activity

Biological Process: behavioral fear response; cellular calcium ion homeostasis; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; positive regulation of fat cell differentiation; positive regulation of phosphatidylinositol biosynthetic process; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of neurological process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; serotonin receptor, phospholipase C activating pathway; synaptic transmission
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 Research Articles on HTR2C    1. Results of the present study do not support a major role of SNPs of HTR2C rs1414334 in the regulation of weight gain or association of serum levels in patients with schizophrenia on clozapine treatment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HTR2C antibodyDiseases associated with anti-HTR2C antibody
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >98 publications with HTR2C and Mental Disorders
 Weight Gain Antibodies  >41 publications with HTR2C and Weight Gain
 Nervous System Diseases Antibodies  >32 publications with HTR2C and Nervous System Diseases
 Obesity Antibodies  >27 publications with HTR2C and Obesity
 Mood Disorders Antibodies  >20 publications with HTR2C and Mood Disorders
 Depressive Disorder Antibodies  >17 publications with HTR2C and Depressive Disorder
 Serotonin Syndrome Antibodies  >17 publications with HTR2C and Serotonin Syndrome
 Bipolar Disorder Antibodies  >17 publications with HTR2C and Bipolar Disorder
 Movement Disorders Antibodies  >14 publications with HTR2C and Movement Disorders
 Depressive Disorder, Major Antibodies  >11 publications with HTR2C and Depressive Disorder, Major
Organs/Tissues associated with anti-HTR2C antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >65 publications with HTR2C and Brain
 Muscle Antibodies  >3 publications with HTR2C and Muscle
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