NP_000861.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,907 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 4 isoform b
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
NCBI Protein Information
5-hydroxytryptamine receptor 4; cardiac 5-HT4 receptor
UniProt Protein Name
5-hydroxytryptamine receptor 4
UniProt Synonym Protein Names
Serotonin receptor 4
UniProt Synonym Gene Names
UniProt Entry Name
5HT4R_HUMAN
NCBI Summary for HTR4
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
UniProt Comments for HTR4
5-HT(4): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q31-q33
Cellular Component: membrane; integral to plasma membrane; cytoplasm; plasma membrane; endosome
Molecular Function: serotonin receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; regulation of appetite; positive regulation of cell proliferation; serotonin receptor signaling pathway
Research Articles on HTR4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-HTR4 antibody
Diseases associated with anti-HTR4 antibody
Organs/Tissues associated with anti-HTR4 antibody
|