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anti-TP53BP1 antibody :: Rabbit 53BP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176333
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

53BP1 (TP53BP1), Polyclonal Antibody

 Also Known As   

Anti-53BP1 antibody

 Product Synonym Names    Tumor suppressor p53-binding protein 1; tumor protein p53 binding protein 1; 53 BP1 antibody; 53BP1 antibody; FLJ41424 antibody; MGC138366 antibody; p202 antibody; p53 binding protein 1 antibody; p53 BP1 antibody; p53-binding protein 1 antibody; p53BP1 antibody; TP53 BP1 antibody; TP53B_HUMAN antibody; TP53BP1 antibody; TRP53 BP1 antibody; Tumor protein 53 binding protein 1 antibody; Tumor protein p53 binding protein 1 antibody; Tumor suppressor p53 binding protein 1 antibody; Tumor suppressor p53-binding protein 1 antibody
 Product Gene Name   

anti-TP53BP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605230
 3D Structure    ModBase 3D Structure for Q12888
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human 53BP1 (1955-1972aa ERIGFKQHPKYKHDYVSH), identical to the related mouse sequence.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TP53BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TP53BP1 antibody

   Description: Rabbit IgG polyclonal antibody for Tumor suppressor p53-binding protein 1(TP53BP1) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Background: TP53BP1(Tumor Protein p53-Binding Protein 1), also called 53BP1, is a protein that in humans is encoded by the TP53BP1 gene. Iwabuchi et al.(1998) mapped the TP53BP1 gene to 15q15-q21 by FISH. Iwabuchi et al.(1994) showed that TP53BP1 binds to the conformationally sensitive central domain of wildtype p53 but not to mutant p53 in vitro. Immunoblot analysis by Iwabuchi et al.(1998) showed that expression of TP53BP1 or TP53BP2 enhances the transactivation function of p53 and induces the expression of p21(CDKN1A). Wang et al.(2002) used small interfering RNA directed against TP53BP1 in mammalian cells to demonstrate that TP53BP1 is a key transducer of the DNA damage checkpoint signal. TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.
 Applications Tested/Suitable for anti-TP53BP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

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 Western Blot (WB) of anti-TP53BP1 antibody    Anti-53BP1 antibody, MBS176333, Western blotting
Lane 1: 293T Cell Lysate
Lane 2: U20S Cell Lysate
Lane 3: HEPA Cell Lysate

anti-TP53BP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TP53BP1 antibody    Anti-53BP1 antibody, MBS176333, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
anti-TP53BP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TP53BP1 antibody    Anti-53BP1 antibody, MBS176333, IHC(P)
IHC(P): Rat Brain Tissue
anti-TP53BP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TP53BP1 antibody    Anti-53BP1 antibody, MBS176333, IHC(P)
IHC(P): Mouse Brain Tissue
anti-TP53BP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunocytochemistry (ICC) of anti-TP53BP1 antibody    Anti-53BP1 antibody, MBS176333, ICC
ICC: A549 Cell
anti-TP53BP1 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for TP53BP1. It may not necessarily be applicable to this product.
 NCBI GI #    8928568
 NCBI GeneID    7158
 NCBI Accession #    Q12888.2 [Other Products]
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 UniProt Primary Accession #    Q12888 [Other Products]
 UniProt Secondary Accession #    Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4; F8VY86 [Other Products]
 UniProt Related Accession #    Q12888 [Other Products]
 Molecular Weight    213,989 Da
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 NCBI Official Full Name    Tumor suppressor p53-binding protein 1
 NCBI Official Synonym Full Names    tumor protein p53 binding protein 1
 NCBI Official Symbol    TP53BP1 [Similar Products]
 NCBI Official Synonym Symbols   
p202; 53BP1
[Similar Products]
 NCBI Protein Information    tumor suppressor p53-binding protein 1; p53BP1; tumor protein 53-binding protein, 1; tumor protein p53-binding protein, 1
 UniProt Protein Name    Tumor suppressor p53-binding protein 1
 Protein Family    Tumor suppressor p53-binding protein
 UniProt Gene Name    TP53BP1 [Similar Products]
 UniProt Synonym Gene Names    53BP1; p53-binding protein 1; p53BP1 [Similar Products]
 UniProt Entry Name    TP53B_HUMAN
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 UniProt Comments for TP53BP1    53BP1: a DNA damage checkpoint protein that interacts with HDAC4 protein to mediate the DNA damage response. Inhibits E2F1-mediated apoptosis in prostate cancer cells. Recruited to double strand breaks via the binding of its Tudor domain to dimethylated H3 K20. Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. Binds to the central domain of p53. Interacts with Artemis. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on S139. Interacts with histone H4 that has been dimethylated at K20. Has low affinity for histone H4 containing monomethylated K20. Does not bind histone H4 containing unmethylated or trimethylated K20. Has low affinity for histone H3 that has been dimethylated on K79. Does not bind unmethylated histone H3. Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Two alternatively spliced human isoforms have been observed.

Protein type: Transcription, coactivator/corepressor; DNA repair, damage

Chromosomal Location of Human Ortholog: 15q15-q21

Cellular Component: nucleoplasm; chromosome, telomeric region; cytoplasm; replication fork; nucleus

Molecular Function: protein binding; p53 binding; damaged DNA binding; telomeric DNA binding; methylated histone residue binding

Biological Process: transcription from RNA polymerase II promoter; double-strand break repair; positive regulation of transcription, DNA-dependent; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination
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 Research Articles on TP53BP1    1. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor target genes and allows pRb activity to be effectively integrated with the DNA damage response.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TP53BP1 antibodyPathways associated with anti-TP53BP1 antibody
 Reference Product  PubMed Publications
 ATM antibody  >111 publications with TP53BP1 and ATM
 H2AFX antibody  >96 publications with TP53BP1 and H2AFX
 BRCA1 antibody  >90 publications with TP53BP1 and BRCA1
 MDC1 antibody  >59 publications with TP53BP1 and MDC1
 RNF8 antibody  >31 publications with TP53BP1 and RNF8
 CHEK2 antibody  >24 publications with TP53BP1 and CHEK2
 RAD50 antibody  >20 publications with TP53BP1 and RAD50
 TP53 antibody  >18 publications with TP53BP1 and TP53
 PAXIP1 antibody  >5 publications with TP53BP1 and PAXIP1
 DCLRE1C antibody  >3 publications with TP53BP1 and DCLRE1C
 Products by Pathway  Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Homologous Recombination Repair Pathway antibodies  Homologous Recombination Repair Pathway Diagram
 Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway antibodies  Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway Diagram
 Recruitment Of Repair And Signaling Proteins To Double-strand Breaks Pathway antibodies  Recruitment Of Repair And Signaling Proteins To Double-strand Breaks Pathway Diagram
Diseases associated with anti-TP53BP1 antibodyOrgans/Tissues associated with anti-TP53BP1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >39 publications with TP53BP1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >13 publications with TP53BP1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >12 publications with TP53BP1 and Adenocarcinoma
 Nervous System Diseases Antibodies  >11 publications with TP53BP1 and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >10 publications with TP53BP1 and Carcinoma, Squamous Cell
 Gastrointestinal Diseases Antibodies  >9 publications with TP53BP1 and Gastrointestinal Diseases
 Ovarian Neoplasms Antibodies  >9 publications with TP53BP1 and Ovarian Neoplasms
 Necrosis Antibodies  >5 publications with TP53BP1 and Necrosis
 Pancreatic Neoplasms Antibodies  >4 publications with TP53BP1 and Pancreatic Neoplasms
 Glioblastoma Antibodies  >4 publications with TP53BP1 and Glioblastoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >33 publications with TP53BP1 and Blood
 Lung Antibodies  >19 publications with TP53BP1 and Lung
 Skin Antibodies  >15 publications with TP53BP1 and Skin
 Prostate Antibodies  >11 publications with TP53BP1 and Prostate
 Bone Antibodies  >10 publications with TP53BP1 and Bone
 Bone Marrow Antibodies  >6 publications with TP53BP1 and Bone Marrow
 Lymph Node Antibodies  >5 publications with TP53BP1 and Lymph Node
 Brain Antibodies  >5 publications with TP53BP1 and Brain
 Thyroid Antibodies  >3 publications with TP53BP1 and Thyroid
 Pancreas Antibodies  >2 publications with TP53BP1 and Pancreas
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