NP_001135451.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
213,989 Da
NCBI Official Full Name
TP53-binding protein 1 isoform 2
NCBI Official Synonym Full Names
tumor protein p53 binding protein 1
NCBI Official Synonym Symbols
TP53; p202; 53BP1; TDRD30; p53BP1 [Similar Products]
NCBI Protein Information
TP53-binding protein 1
UniProt Protein Name
TP53-binding protein 1
UniProt Synonym Gene Names
NCBI Summary for 53BP1
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
UniProt Comments for 53BP1
Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (). In contrast, it is not required for classic NHEJ and V(D)J recombination (). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112).
Product References and Citations for anti-53BP1 antibody
Iwabuchi K., J. Biol. Chem. 273:26061-26068(1998). The MGC Project Team; Genome Res. 14:2121-2127(2004). Iwabuchi K., Proc. Natl. Acad. Sci. U.S.A. 91:6098-6102(1994).
Research Articles on 53BP1
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Products associated with anti-53BP1 antibody
Pathways associated with anti-53BP1 antibody
Diseases associated with anti-53BP1 antibody
Organs/Tissues associated with anti-53BP1 antibody
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