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anti-53BP1 antibody :: Rabbit anti-Human 53BP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9409587
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

53BP1, Polyclonal Antibody

 Also Known As   

53BP1 (Ab-29) Antibody

 Product Synonym Names    p53-binding protein 1; P531; TP53B; TP53BP1; TRP53BP1
 Product Gene Name   

anti-53BP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605230
 3D Structure    ModBase 3D Structure for Q12888
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody detects endogenous levels of total 53BP1 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthesized peptide derived from Internal of human 53BP1.
 Target Name    53BP1
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-53BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-53BP1 antibody

   Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.Iwabuchi K., J. Biol. Chem. 273:26061-26068(1998).Nakajima D., Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.Bechtel S., BMC Genomics 8:399-399(2007).
 Product Categories/Family for anti-53BP1 antibody    Total protein Ab
 Applications Tested/Suitable for anti-53BP1 antibody   

Western Blot (WB)

 Application Notes for anti-53BP1 antibody    Western blotting: 1:500~1:3000
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 Western Blot (WB) of anti-53BP1 antibody    Western blot analysis of extracts from Jurkat cells and HUVEC cells, using 53BP1 (Ab-29) antibody.
anti-53BP1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-53BP1 antibody    Western blot analysis of extracts from 293 cells (Lane 2), using 53BP1 (Ab-29) antiobdy. The lane on the left is treated with synthesized peptide.
anti-53BP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for 53BP1. It may not necessarily be applicable to this product.
 NCBI GI #    213972634
 NCBI GeneID    7158
 NCBI Accession #    NP_001135451.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001141979.1 [Other Products]
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 UniProt Primary Accession #    Q12888 [Other Products]
 UniProt Secondary Accession #    Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4; F8VY86 [Other Products]
 UniProt Related Accession #    Q12888 [Other Products]
 Molecular Weight    213,989 Da
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 NCBI Official Full Name    tumor suppressor p53-binding protein 1 isoform 2
 NCBI Official Synonym Full Names    tumor protein p53 binding protein 1
 NCBI Official Symbol    TP53BP1 [Similar Products]
 NCBI Official Synonym Symbols   
p202; 53BP1; p53BP1
[Similar Products]
 NCBI Protein Information    tumor suppressor p53-binding protein 1
 UniProt Protein Name    Tumor suppressor p53-binding protein 1
 UniProt Gene Name    TP53BP1 [Similar Products]
 UniProt Synonym Gene Names    53BP1; p53-binding protein 1; p53BP1 [Similar Products]
 UniProt Entry Name    TP53B_HUMAN
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 UniProt Comments for 53BP1    53BP1: a DNA damage checkpoint protein that interacts with HDAC4 protein to mediate the DNA damage response. Inhibits E2F1-mediated apoptosis in prostate cancer cells. Recruited to double strand breaks via the binding of its Tudor domain to dimethylated H3 K20. Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. Binds to the central domain of p53. Interacts with Artemis. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on S139. Interacts with histone H4 that has been dimethylated at K20. Has low affinity for histone H4 containing monomethylated K20. Does not bind histone H4 containing unmethylated or trimethylated K20. Has low affinity for histone H3 that has been dimethylated on K79. Does not bind unmethylated histone H3. Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Two alternatively spliced human isoforms have been observed.

Protein type: Transcription, coactivator/corepressor; DNA repair, damage

Chromosomal Location of Human Ortholog: 15q15-q21

Cellular Component: nucleoplasm; chromosome, telomeric region; cytoplasm; replication fork; nucleus

Molecular Function: protein binding; p53 binding; damaged DNA binding; telomeric DNA binding; methylated histone residue binding

Biological Process: transcription from RNA polymerase II promoter; double-strand break repair; positive regulation of transcription, DNA-dependent; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination
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 Research Articles on 53BP1    1. Depletion of RNF8 or RNF168 blocks the degradation of diffusely localized nuclear 53BP1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-53BP1 antibodyPathways associated with anti-53BP1 antibody
 Reference Product  PubMed Publications
 ATM antibody  >123 publications with 53BP1 and ATM
 H2AFX antibody  >107 publications with 53BP1 and H2AFX
 BRCA1 antibody  >98 publications with 53BP1 and BRCA1
 MDC1 antibody  >62 publications with 53BP1 and MDC1
 RNF8 antibody  >36 publications with 53BP1 and RNF8
 RNF168 antibody  >34 publications with 53BP1 and RNF168
 CHEK2 antibody  >24 publications with 53BP1 and CHEK2
 TP53 antibody  >22 publications with 53BP1 and TP53
 PAXIP1 antibody  >6 publications with 53BP1 and PAXIP1
 CHEK1 antibody  >2 publications with 53BP1 and CHEK1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 G2/M Checkpoints Pathway antibodies  G2/M Checkpoints Pathway Diagram
 G2/M DNA Damage Checkpoint Pathway antibodies  G2/M DNA Damage Checkpoint Pathway Diagram
 Homologous Recombination Repair Pathway antibodies  Homologous Recombination Repair Pathway Diagram
 Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway antibodies  Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway Diagram
 Recruitment Of Repair And Signaling Proteins To Double-strand Breaks Pathway antibodies  Recruitment Of Repair And Signaling Proteins To Double-strand Breaks Pathway Diagram
Diseases associated with anti-53BP1 antibodyOrgans/Tissues associated with anti-53BP1 antibody
 Disease Name  Pubmed Publications
 Ataxia Antibodies  >104 publications with 53BP1 and Ataxia
 Breast Neoplasms Antibodies  >43 publications with 53BP1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >15 publications with 53BP1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >14 publications with 53BP1 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >13 publications with 53BP1 and Carcinoma, Squamous Cell
 Nervous System Diseases Antibodies  >11 publications with 53BP1 and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >10 publications with 53BP1 and Gastrointestinal Diseases
 Ovarian Neoplasms Antibodies  >9 publications with 53BP1 and Ovarian Neoplasms
 Pancreatic Neoplasms Antibodies  >6 publications with 53BP1 and Pancreatic Neoplasms
 Uterine Cervical Neoplasms Antibodies  >5 publications with 53BP1 and Uterine Cervical Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >36 publications with 53BP1 and Blood
 Lung Antibodies  >21 publications with 53BP1 and Lung
 Skin Antibodies  >16 publications with 53BP1 and Skin
 Prostate Antibodies  >11 publications with 53BP1 and Prostate
 Bone Antibodies  >11 publications with 53BP1 and Bone
 Bone Marrow Antibodies  >7 publications with 53BP1 and Bone Marrow
 Lymph Node Antibodies  >6 publications with 53BP1 and Lymph Node
 Brain Antibodies  >6 publications with 53BP1 and Brain
 Thyroid Antibodies  >3 publications with 53BP1 and Thyroid
 Pancreas Antibodies  >2 publications with 53BP1 and Pancreas
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