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anti-FTCD antibody :: Goat 58KGolgi protein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420986
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

58KGolgi protein (FTCD), Polyclonal Antibody

 Also Known As   

Goat anti-58KGolgi protein(Internal)/FTCD Antibody

 Product Synonym Names    Goat Anti-58K Golgi protein(N-Term)/FTCD, Biotinylated Antibody; FTCD; LCHC1; formiminotransferase cyclodeaminase; formimidoyltransferase cyclodeaminase; LC1 autoantigen; FTCD antibody; LCHC1 antibody; formiminotransferase cyclodeaminase antibody; formimidoyltransferase cyclodeaminase antibody; LC1 autoantigen antibody; 58KGolgi protein; 58KGolgi protein(Internal)/FTCD
 Product Gene Name   

anti-FTCD antibody

[Similar Products]
 Antibody/Peptide Pairs    58KGolgi protein/FTCD peptide (MBS426972) is used for blocking the activity of 58KGolgi protein antibody (MBS420986)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    CLREQGRGKD QPGRL
 OMIM    229100
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence CLREQGRGKDQPGRL, from the internal region of the protein sequence according to NP_006648.1; NP_996848.1.
 Epitope    Internal region
 Note    Variants (NP_006648.1; NP_996848.1) encode the same protein.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-FTCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FTCD antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-FTCD antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Liver shows distinct staining of membranes and cytoplasm in a selection of hepatocytes. Recommended concentration, 3-5ug/ml.
Western Blot: Approx 60kDa band observed in Human Liver lysates (calculated MW of 58.9kDa according to NP_006648.1and NP_996848.1). Recommended concentration: 0.01-0.03ug/ml.
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 Western Blot (WB) of anti-FTCD antibody    Staining (0. 01ug/ml) of Human Liver lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-FTCD antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-FTCD antibody    (3.8ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-FTCD antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FTCD. It may not necessarily be applicable to this product.
 NCBI GI #    11140815
 NCBI GeneID    10841
 NCBI Accession #    NP_006648.1 [Other Products]
 NCBI Related Accession #    NP_996848.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006657.2 [Other Products]
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 UniProt Secondary Accession #    Q86V03; Q9HCT4; Q9HCT5; Q9HCT6; Q9UHJ2; B9EGD0 [Other Products]
 UniProt Related Accession #    O95954 [Other Products]
 Molecular Weight    16,503 Da
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 NCBI Official Full Name    formimidoyltransferase-cyclodeaminase isoform A
 NCBI Official Synonym Full Names    formimidoyltransferase cyclodeaminase
 NCBI Official Symbol    FTCD [Similar Products]
 NCBI Official Synonym Symbols   
LCHC1
[Similar Products]
 NCBI Protein Information    formimidoyltransferase-cyclodeaminase
 UniProt Protein Name    Formimidoyltransferase-cyclodeaminase
 UniProt Synonym Protein Names   
Formiminotransferase-cyclodeaminase; FTCD; LCHC1Including the following 2 domains:Glutamate formimidoyltransferase (EC:2.1.2.5)Alternative name(s):Glutamate formiminotransferase; Glutamate formyltransferase
 Protein Family    Formimidoyltransferase-cyclodeaminase
 UniProt Gene Name    FTCD [Similar Products]
 UniProt Synonym Gene Names    FTCD [Similar Products]
 UniProt Entry Name    FTCD_HUMAN
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 NCBI Summary for FTCD    The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
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 UniProt Comments for FTCD    FTCD: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA); also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - histidine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.5; EC 4.3.1.4; Lyase; Methyltransferase

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; ER-Golgi intermediate compartment; Golgi apparatus; Golgi membrane; smooth endoplasmic reticulum membrane

Molecular Function: formimidoyltetrahydrofolate cyclodeaminase activity; formimidoyltransferase activity; microtubule binding; protein binding

Biological Process: folic acid and derivative metabolic process; histidine catabolic process

Disease: Formiminotransferase Deficiency
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 Research Articles on FTCD    1. FTCD is a positive regulator of the hypoxia-HIF signaling pathway and has an important role in cell proliferation, metabolism and migration in HepG2 cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FTCD antibodyPathways associated with anti-FTCD antibody
 Reference Product  PubMed Publications
 MTR antibody  >1 publications with FTCD and MTR
 SHMT1 antibody  >1 publications with FTCD and SHMT1
 MTHFD1L antibody  >1 publications with FTCD and MTHFD1L
 Products by Pathway  Pathway Diagram
 Histidine Catabolism Pathway antibodies  Histidine Catabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway antibodies  Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
Diseases associated with anti-FTCD antibodyOrgans/Tissues associated with anti-FTCD antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >14 publications with FTCD and Brain Diseases
 Liver Diseases Antibodies  >13 publications with FTCD and Liver Diseases
 Hepatitis Antibodies  >12 publications with FTCD and Hepatitis
 Disease Models, Animal Antibodies  >5 publications with FTCD and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >5 publications with FTCD and Neurobehavioral Manifestations
 Glutamate formiminotransferase deficiency Antibodies  >4 publications with FTCD and Glutamate formiminotransferase deficiency
 Cognition Disorders Antibodies  >4 publications with FTCD and Cognition Disorders
 Liver Neoplasms Antibodies  >3 publications with FTCD and Liver Neoplasms
 Inflammation Antibodies  >3 publications with FTCD and Inflammation
 Carcinoma, Hepatocellular Antibodies  >3 publications with FTCD and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >67 publications with FTCD and Brain
 Liver Antibodies  >19 publications with FTCD and Liver
 Kidney Antibodies  >4 publications with FTCD and Kidney
 Eye Antibodies  >3 publications with FTCD and Eye
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