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anti-5HT1B antibody :: Rabbit 5HT1B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540154 anti-5HT1B antibody
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5HT1B, Polyclonal Antibody

 Also Known As   

5HT1B Receptor Antibody Affinity Purified

 Product Synonym Names    HTR1DB; S12; Serotonin 1D beta receptor antibody
 Product Gene Name   

anti-5HT1B antibody

[Similar Products]
 Antibody/Peptide Pairs    5HT1B peptide (MBS542301) is used for blocking the activity of 5HT1B antibody (MBS540154)
 Matching Pairs    Antibody: 5HT1B (MBS540154)
Positive Control: 5HT1B (MBS542495)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P28334
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    Affinity Purified
 Concentration    0.5-1.5 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 160-260 on rat 5HT1B
 Molecular Function    Drug binding, serotonin receptor activity, serotonin binding
 Structure    Homodimer. Heterodimer with HTR1D
 Subcellular Location    Cell membrane; Multi-pass protein
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-5HT1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-5HT1B antibody

   Affinity Purified 5 Hydroxytryptamine 1B receptor Antibody
G-protein coupled receptor for serotonin (5-hydroxytryptamine). Functions as a receptor for various drugs which cause conformational change upon ligand binding that triggers signaling via guanine nucleo-tide binding proteins and modulation of down-stream effectors like adenylate cyclase. Inhibits adenylate cyclase activity and activates phosphatidylinositol-calcium second messenger system that regulates release of intracellular Calcium ions.
 Product Categories/Family for anti-5HT1B antibody    Primary Antibodies; Neuroscience; Neurotransmission; 5HT1B Antibody
 Applications Tested/Suitable for anti-5HT1B antibody   

ELISA (EIA), IMM, Western Blot (WB)

 Application Notes for anti-5HT1B antibody    Dot Blot: 1:50,000
ELISA: 1:50,000
Immunoprecipitation: 1:200
Western Blot: 1:2,500-1:5,000
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NCBI/Uniprot data below describe general gene information for 5HT1B. It may not necessarily be applicable to this product.
 NCBI GI #    112814
 NCBI GeneID    15551
 NCBI Accession #    P28334.1 [Other Products]
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 UniProt Primary Accession #    P28334 [Other Products]
 UniProt Related Accession #    P28334 [Other Products]
 Molecular Weight    43,079 Da
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 NCBI Official Full Name    5-hydroxytryptamine receptor 1B
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 1B
 NCBI Official Symbol    Htr1b [Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 1B
 UniProt Protein Name    5-hydroxytryptamine receptor 1B
 UniProt Synonym Protein Names   
Serotonin receptor 1B
 UniProt Gene Name    Htr1b [Similar Products]
 UniProt Synonym Gene Names    5ht1b; 5-HT-1B; 5-HT1B [Similar Products]
 UniProt Entry Name    5HT1B_MOUSE
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 UniProt Comments for 5HT1B    5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Cellular Component: cytoplasm; integral to membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: drug binding; G-protein coupled receptor activity; serotonin binding; serotonin receptor activity; signal transducer activity

Biological Process: behavior; bone remodeling; drinking behavior; feeding behavior; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; negative regulation of cAMP biosynthetic process; negative regulation of serotonin secretion; negative regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; protein kinase C activation; regulation of behavior; regulation of dopamine secretion; response to cocaine; response to drug; response to ethanol; response to toxin; serotonin receptor, adenylate cyclase inhibiting pathway; signal transduction; synaptic transmission; vasoconstriction
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 Research Articles on 5HT1B    1. 5-HT1B Knockout and pharmacologic 5-HT1B antagonism both attenuated locomotor hyperactivity in dopamine transporter Knockout mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-5HT1B antibodyPathways associated with anti-5HT1B antibody
 Reference Product  PubMed Publications
 Htr1a antibody  >40 publications with 5HT1B and Htr1a
 Npy antibody  >3 publications with 5HT1B and Npy
 Cnr1 antibody  >2 publications with 5HT1B and Cnr1
 Grm7 antibody  >2 publications with 5HT1B and Grm7
 Grm8 antibody  >1 publications with 5HT1B and Grm8
 Pomc antibody  >1 publications with 5HT1B and Pomc
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Non-odorant GPCRs Pathway antibodies  Non-odorant GPCRs Pathway Diagram
Diseases associated with anti-5HT1B antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >100 publications with 5HT1B and Mental Disorders
 Nervous System Diseases Antibodies  >51 publications with 5HT1B and Nervous System Diseases
 Brain Diseases Antibodies  >42 publications with 5HT1B and Brain Diseases
 Migraine Disorders Antibodies  >40 publications with 5HT1B and Migraine Disorders
 Headache Antibodies  >25 publications with 5HT1B and Headache
 Depressive Disorder Antibodies  >19 publications with 5HT1B and Depressive Disorder
 Pain Antibodies  >18 publications with 5HT1B and Pain
 Anxiety Disorders Antibodies  >17 publications with 5HT1B and Anxiety Disorders
 Inflammation Antibodies  >10 publications with 5HT1B and Inflammation
 Hypothermia Antibodies  >8 publications with 5HT1B and Hypothermia
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