NP_001026854.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,012 Da
NCBI Official Full Name
serine/arginine-rich splicing factor 7 isoform 1
NCBI Official Synonym Full Names
serine/arginine-rich splicing factor 7
NCBI Protein Information
serine/arginine-rich splicing factor 7
UniProt Protein Name
Serine/arginine-rich splicing factor 7
UniProt Synonym Protein Names
Splicing factor 9G8; Splicing factor, arginine/serine-rich 7
UniProt Synonym Gene Names
UniProt Entry Name
SRSF7_HUMAN
NCBI Summary for 9G8
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
UniProt Comments for 9G8
SFRS7: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. Belongs to the splicing factor SR family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA splicing; Spliceosome; RNA-binding
Chromosomal Location of Human Ortholog: 2p22.1
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; zinc ion binding; nucleotide binding
Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription
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Pathways associated with anti-9G8 antibody
Organs/Tissues associated with anti-9G8 antibody
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