Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow ADCY1 rightarrow Polyclonal ADCY1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • HMGB1 Antibody
 • REN Antibody
 • HBA2 Recombinant Protein
 • Apoptosis Signal Regulating Kinase 1 (ASK1) ELISA Kit
 • 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 ELISA Kit
 • S100A9 Antibody
 • DCX - Doublecortin Antibody
 • TBC1D2 cDNA Clone
 • Sm IgG ELISA Kit
 • Interleukin 6 (IL6) ELISA Kit
 • Goat anti Human IgG (Fab'2) (PE) Secondary Antibody
 • HBB Antibody
 • Dermcidin, aa96-110 (DCD) Antibody
 • Gamma Glutamyl Transpeptidase (GGT) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-ADCY1 antibody :: Rabbit anti-Human A Cyclase I Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9602044
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Cyclase I (ADCY1), Polyclonal Antibody

★Popular Item★
 Also Known As   

A Cyclase I Antibody

 Product Synonym Names    Adenylate cyclase 1, fetal brain, type I; 3', 5'-cyclic AMP synthetase; AC1; Adcy1; ADCY1_HUMAN; adenyl cyclase; Adenylate cyclase 1; adenylate cyclase 1 (brain); Adenylate cyclase type 1; Adenylate cyclase type I; Adenylyl cyclase 1; ATP pyrophosphate lyase; ATP pyrophosphate-lyase 1; Brain adenylate cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase; deafness, autosomal recessive 44; DFNB44
 Product Gene Name   

anti-ADCY1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for Q08828
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Specificity    A Cyclase I antibody detects endogenous levels of total A Cyclase I
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
Section Bar
 Immunogen    A synthesized peptide derived from human A Cyclase I
 Subcellular Location    Membrane.
 Tissue Specificity    Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla.
 Conjugation    Unconjugated
Section Bar
 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-ADCY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-ADCY1 antibody

   Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).
Subunit Structure: Interacts with CALM.
Post-translational Modifications: N-glycosylated.
Similarity: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
 Applications Tested/Suitable for anti-ADCY1 antibody   

Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

 Application Notes for anti-ADCY1 antibody    WB: 1:1000
IF/ICC: 1:100-1:500
Section Bar
 Immunofluorescence (IF) of anti-ADCY1 antibody    MBS9602044 staining COLO205 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
anti-ADCY1 antibody Immunofluorescence (IF) image
Section Bar
 Western Blot (WB) of anti-ADCY1 antibody    Western blot analysis of A Cyclase I using COLO205 whole cell lysates
anti-ADCY1 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ADCY1. It may not necessarily be applicable to this product.
 NCBI GI #    31083193
 NCBI GeneID    107
 NCBI Accession #    NP_066939.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021116.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q08828 [Other Products]
 UniProt Secondary Accession #    Q75MI1; A4D2L8 [Other Products]
 UniProt Related Accession #    Q08828 [Other Products]
 Molecular Weight    Observed: 130 kDa
Predicted: 124 kDa
Table BarTOPTable Bar
 NCBI Official Full Name    adenylate cyclase type 1 isoform 1
 NCBI Official Synonym Full Names    adenylate cyclase 1
 NCBI Official Symbol    ADCY1 [Similar Products]
 NCBI Official Synonym Symbols   
AC1; DFNB44
[Similar Products]
 NCBI Protein Information    adenylate cyclase type 1
 UniProt Protein Name    Adenylate cyclase type 1
 UniProt Synonym Protein Names   
ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase
 Protein Family    Adenylate cyclase
 UniProt Gene Name    ADCY1 [Similar Products]
Section Bar
 NCBI Summary for ADCY1    This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Section Bar
 UniProt Comments for ADCY1    Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina ().
Table BarTOPTable Bar
 Research Articles on ADCY1    1. data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-ADCY1 antibodyPathways associated with anti-ADCY1 antibody
 Reference Product  PubMed Publications
 DRD4 antibody  >2 publications with ADCY1 and DRD4
 ADCY2 antibody  >2 publications with ADCY1 and ADCY2
 Products by Pathway  Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adenylate Cyclase Activating Pathway antibodies  Adenylate Cyclase Activating Pathway Diagram
 Adenylate Cyclase Inhibitory Pathway antibodies  Adenylate Cyclase Inhibitory Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 CREB Phosphorylation Through The Activation Of Adenylate Cyclase Pathway antibodies  CREB Phosphorylation Through The Activation Of Adenylate Cyclase Pathway Diagram
Diseases associated with anti-ADCY1 antibodyOrgans/Tissues associated with anti-ADCY1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with ADCY1 and Neoplasms
 Nervous System Diseases Antibodies  >1 publications with ADCY1 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >6 publications with ADCY1 and Eye
 Brain Antibodies  >6 publications with ADCY1 and Brain
 Embryonic Tissue Antibodies  >3 publications with ADCY1 and Embryonic Tissue
 Nerve Antibodies  >2 publications with ADCY1 and Nerve
 Kidney Antibodies  >2 publications with ADCY1 and Kidney
 Bone Antibodies  >1 publications with ADCY1 and Bone
 Heart Antibodies  >1 publications with ADCY1 and Heart
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions