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| Product Name
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A Cyclase IV (ADCY4), Polyclonal Antibody
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| Also Known As
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A Cyclase IV Polyclonal Antibody
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| Product Synonym Names
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ADCY4; Adenylate cyclase type 4; ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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AF497516 mRNA
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| 3D Structure
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ModBase 3D Structure for Q8NFM4
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| Clonality
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Polyclonal
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| Host
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Rabbit
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| Species Reactivity
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Human, Mouse, Rat
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| Specificity
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A Cyclase IV Polyclonal Antibody detects endogenous levels of A Cyclase IV protein.
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| Purity/Purification
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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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| Form/Format
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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| Concentration
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1 mg/ml (lot specific)
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| Immunogen
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Synthesized peptide derived from the Internal region of human A Cyclase IV. at AA rangle: 170-250
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| Preparation and Storage
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Store at -20 degree C/1 year
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| Other Notes
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Small volumes of anti-ADCY4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Applications Tested/Suitable for anti-ADCY4 antibody
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Western Blot (WB), ELISA (EIA)
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| Application Notes for anti-ADCY4 antibody
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Western Blot: 1/500 - 1/2000
ELISA: 1/20000
Not yet tested in other applications.
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TOP
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| NCBI/Uniprot data below describe general gene information for ADCY4. It may not necessarily be applicable to this product. |
| NCBI GI #
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310832386
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| NCBI GeneID
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196883
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| NCBI Accession #
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NP_001185497.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001198568.1
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[Other Products]
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| UniProt Primary Accession #
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Q8NFM4
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[Other Products]
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| UniProt Secondary Accession #
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Q17R40; Q6ZTM6; Q96ML7; B3KV74; D3DS75
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[Other Products]
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| UniProt Related Accession #
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Q8NFM4
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[Other Products]
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| Molecular Weight
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119.794
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TOP
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| NCBI Official Full Name
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adenylate cyclase type 4
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| NCBI Official Synonym Full Names
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adenylate cyclase 4
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| NCBI Official Symbol
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ADCY4
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[Similar Products]
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| NCBI Official Synonym Symbols
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AC4
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[Similar Products]
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| NCBI Protein Information
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adenylate cyclase type 4
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| UniProt Protein Name
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Adenylate cyclase type 4
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| UniProt Synonym Protein Names
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ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4
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| Protein Family
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Adenylate cyclase
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| UniProt Gene Name
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ADCY4
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[Similar Products]
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| NCBI Summary for ADCY4
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This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
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| UniProt Comments for ADCY4
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ADCY4: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: cytoplasm; membrane; plasma membrane
Molecular Function: adenylate cyclase activity; protein binding
Biological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; renal water homeostasis
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TOP
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| Research Articles on ADCY4
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1. AC4 and AC2, both isoforms stimulated by Gbetagamma, are expressed in bronchial nonlipid raft membrane fractions where they colocalize with and couple to prostanoid EP2 receptors.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Pathways associated with anti-ADCY4 antibody | Diseases associated with anti-ADCY4 antibody |
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| Organs/Tissues associated with anti-ADCY4 antibody |
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TOP
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Antibody 
