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anti-ADCY5 antibody :: Rabbit A Cyclase V/VI Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8521013 anti-ADCY5 antibody
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Cyclase V/VI (ADCY5), Polyclonal Antibody

 Also Known As   

A Cyclase V/VI Polyclonal Antibody

 Product Synonym Names    ADCY5; Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; ADCY6; KIAA0422; Adenylate cyclase type 6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca (2+)-inhibitabl
 Product Gene Name   

anti-ADCY5 antibody

[Similar Products]
 Product Synonym Gene Name    ADCY6 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AK303070 mRNA
 3D Structure    ModBase 3D Structure for O95622
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    A Cyclase V/VI Polyclonal Antibody detects endogenous levels of A Cyclase V/VI protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the C-terminal region of human A Cyclase V/VI. at AA rangle: 900-980
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-ADCY5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADCY5 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-ADCY5 antibody    Western Blot: 1/500 - 1/2000
Immunohistochemistry: 1/100 - 1/300
Immunofluorescence: 1/200 - 1/1000
ELISA: 1/10000
Not yet tested in other applications.
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NCBI/Uniprot data below describe general gene information for ADCY5. It may not necessarily be applicable to this product.
 NCBI GI #    314122162
 NCBI GeneID    111
 NCBI Accession #    NP_001186571.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199642.1 [Other Products]
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 UniProt Primary Accession #    O95622 [Other Products]
 UniProt Secondary Accession #    Q7RTV7; Q8NFM3; B7Z8A6 [Other Products]
 UniProt Related Accession #    O95622 [Other Products]
 Molecular Weight    138.908
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 NCBI Official Full Name    adenylate cyclase type 5 isoform 2
 NCBI Official Synonym Full Names    adenylate cyclase 5
 NCBI Official Symbol    ADCY5 [Similar Products]
 NCBI Official Synonym Symbols   
AC5; FDFM
[Similar Products]
 NCBI Protein Information    adenylate cyclase type 5
 UniProt Protein Name    Adenylate cyclase type 5
 UniProt Synonym Protein Names   
ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5
 Protein Family    Adenylate cyclase
 UniProt Gene Name    ADCY5 [Similar Products]
 UniProt Synonym Gene Names    AC5 [Similar Products]
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 NCBI Summary for ADCY5    This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for ADCY5    ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 3q21.1

Cellular Component: cilium; integral to membrane; plasma membrane

Molecular Function: adenylate cyclase activity; adenylate cyclase binding; protein heterodimerization activity

Biological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; renal water homeostasis

Disease: Dyskinesia, Familial, With Facial Myokymia
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 Research Articles on ADCY5    1. This study showed that ADCY5 mutation carriers display pleiotropic paroxysmal day and nighttime dyskinesias.(
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADCY5 antibodyPathways associated with anti-ADCY5 antibody
 Reference Product  PubMed Publications
 ADRA2A antibody  >6 publications with ADCY5 and ADRA2A
 MTNR1B antibody  >5 publications with ADCY5 and MTNR1B
 GIPR antibody  >4 publications with ADCY5 and GIPR
 ADCY2 antibody  >2 publications with ADCY5 and ADCY2
 Products by Pathway  Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Adenylate Cyclase Activating Pathway antibodies  Adenylate Cyclase Activating Pathway Diagram
 Adenylate Cyclase Inhibitory Pathway antibodies  Adenylate Cyclase Inhibitory Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
Diseases associated with anti-ADCY5 antibodyOrgans/Tissues associated with anti-ADCY5 antibody
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >13 publications with ADCY5 and Diabetes Mellitus, Type 2
 Birth Weight Antibodies  >8 publications with ADCY5 and Birth Weight
 Nervous System Diseases Antibodies  >2 publications with ADCY5 and Nervous System Diseases
 Depressive Disorder Antibodies  >1 publications with ADCY5 and Depressive Disorder
 Substance Withdrawal Syndrome Antibodies  >1 publications with ADCY5 and Substance Withdrawal Syndrome
 Movement Disorders Antibodies  >1 publications with ADCY5 and Movement Disorders
 Hypertension Antibodies  >1 publications with ADCY5 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with ADCY5 and Blood
 Heart Antibodies  >3 publications with ADCY5 and Heart
 Nerve Antibodies  >2 publications with ADCY5 and Nerve
 Brain Antibodies  >2 publications with ADCY5 and Brain
 Lung Antibodies  >1 publications with ADCY5 and Lung
 Prostate Antibodies  >1 publications with ADCY5 and Prostate
 Pancreas Antibodies  >1 publications with ADCY5 and Pancreas
 Placenta Antibodies  >1 publications with ADCY5 and Placenta
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