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anti-ADCY5 antibody :: Rabbit A Cyclase V/VI Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8521014 anti-ADCY5 antibody
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Cyclase V/VI (ADCY5), Polyclonal Antibody

 Also Known As   

A Cyclase V/VI Polyclonal Antibody

 Product Synonym Names    ADCY6; KIAA0422; Adenylate cyclase type 6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca (2+)-inhibitable adenylyl cyclase; ADCY5; Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V
 Product Gene Name   

anti-ADCY5 antibody

[Similar Products]
 Product Synonym Gene Name    ADCY6 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF250226 mRNA
 3D Structure    ModBase 3D Structure for O43306
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    A Cyclase V/VI Polyclonal Antibody detects endogenous levels of A Cyclase V/VI protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the C-terminal region of human A Cyclase V/VI. at AA rangle: 900-980
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-ADCY5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADCY5 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-ADCY5 antibody    Immunohistochemistry: 1/100 - 1/300
Immunofluorescence: 1/200 - 1/1000
ELISA: 1/20000
Not yet tested in other applications.
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NCBI/Uniprot data below describe general gene information for ADCY5. It may not necessarily be applicable to this product.
 NCBI GI #    10181096
 NCBI GeneID    112
 NCBI Accession #    NP_056085.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_015270.4 [Other Products]
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 UniProt Primary Accession #    O43306 [Other Products]
 UniProt Secondary Accession #    Q9NR75; Q9UDB0 [Other Products]
 UniProt Related Accession #    O43306 [Other Products]
 Molecular Weight    130.615
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 NCBI Official Full Name    adenylate cyclase type 6
 NCBI Official Synonym Full Names    adenylate cyclase 6
 NCBI Official Symbol    ADCY6 [Similar Products]
 NCBI Official Synonym Symbols   
AC6; LCCS8
[Similar Products]
 NCBI Protein Information    adenylate cyclase type 6
 UniProt Protein Name    Adenylate cyclase type 6
 UniProt Synonym Protein Names   
ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6
 Protein Family    Adenylate cyclase
 UniProt Gene Name    ADCY6 [Similar Products]
 UniProt Synonym Gene Names    KIAA0422 [Similar Products]
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 NCBI Summary for ADCY5    This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015]
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 UniProt Comments for ADCY5    ADCY6: a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Expressed in normal thyroid and brain tissues, as well as some tumors; its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.

Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: intrinsic to plasma membrane; membrane; plasma membrane

Molecular Function: adenylate cyclase activity; protein binding; protein kinase binding

Biological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; dopamine receptor signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of vasodilation; renal water homeostasis

Disease: Lethal Congenital Contracture Syndrome 8
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 Research Articles on ADCY5    1. Sickle cell anemia patients carrying at least one allele of adcy6 rs3730070-G exhibited lower hemolytic rate than non-carriers in univariate analysis (p=0.006).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADCY5 antibodyPathways associated with anti-ADCY5 antibody
 Reference Product  PubMed Publications
 GNAS antibody  >1 publications with ADCY5 and GNAS
 Products by Pathway  Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Adenylate Cyclase Activating Pathway antibodies  Adenylate Cyclase Activating Pathway Diagram
 Adenylate Cyclase Inhibitory Pathway antibodies  Adenylate Cyclase Inhibitory Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
Diseases associated with anti-ADCY5 antibodyOrgans/Tissues associated with anti-ADCY5 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with ADCY5 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with ADCY5 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with ADCY5 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with ADCY5 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with ADCY5 and Blood
 Heart Antibodies  >2 publications with ADCY5 and Heart
 Eye Antibodies  >1 publications with ADCY5 and Eye
 Larynx Antibodies  >1 publications with ADCY5 and Larynx
 Kidney Antibodies  >1 publications with ADCY5 and Kidney
 Muscle Antibodies  >1 publications with ADCY5 and Muscle
 Uncharacterized Tissue Antibodies  >1 publications with ADCY5 and Uncharacterized Tissue
 Ovary Antibodies  >1 publications with ADCY5 and Ovary
 Brain Antibodies  >1 publications with ADCY5 and Brain
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