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anti-ADCY8 antibody :: Rabbit A Cyclase VIII Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8521016 anti-ADCY8 antibody
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Cyclase VIII (ADCY8), Polyclonal Antibody

 Also Known As   

A Cyclase VIII Polyclonal Antibody

 Product Synonym Names    ADCY8; Adenylate cyclase type 8; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca (2+)/calmodulin-activated adenylyl cyclase
 Product Gene Name   

anti-ADCY8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    Z35309 mRNA
 3D Structure    ModBase 3D Structure for P40145
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    A Cyclase VIII Polyclonal Antibody detects endogenous levels of A Cyclase VIII protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the Internal region of human A Cyclase VIII. at AA rangle: 560-640
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-ADCY8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADCY8 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-ADCY8 antibody    Immunohistochemistry: 1/100 - 1/300
Immunofluorescence: 1/200 - 1/1000
ELISA: 1/40000
Not yet tested in other applications.
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NCBI/Uniprot data below describe general gene information for ADCY8. It may not necessarily be applicable to this product.
 NCBI GI #    4557257
 NCBI GeneID    114
 NCBI Accession #    NP_001106.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001115.2 [Other Products]
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 UniProt Primary Accession #    P40145 [Other Products]
 UniProt Related Accession #    P40145 [Other Products]
 Molecular Weight    140.122
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 NCBI Official Full Name    adenylate cyclase type 8
 NCBI Official Synonym Full Names    adenylate cyclase 8
 NCBI Official Symbol    ADCY8 [Similar Products]
 NCBI Official Synonym Symbols   
AC8; ADCY3; HBAC1
[Similar Products]
 NCBI Protein Information    adenylate cyclase type 8
 UniProt Protein Name    Adenylate cyclase type 8
 UniProt Synonym Protein Names   
ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII
 Protein Family    Adenylate cyclase
 UniProt Gene Name    ADCY8 [Similar Products]
 UniProt Synonym Gene Names    AC8 [Similar Products]
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 NCBI Summary for ADCY8    Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADCY8    ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 8q24.22

Cellular Component: membrane; plasma membrane

Molecular Function: adenylate cyclase activity; calcium- and calmodulin-responsive adenylate cyclase activity

Biological Process: activation of protein kinase A; adenylate cyclase activation; cAMP-mediated signaling; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; learning and/or memory; renal water homeostasis; signal transduction
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 Research Articles on ADCY8    1. ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ADCY8 antibodyDiseases associated with anti-ADCY8 antibody
 Products by Pathway  Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adenylate Cyclase Activating Pathway antibodies  Adenylate Cyclase Activating Pathway Diagram
 Adenylate Cyclase Inhibitory Pathway antibodies  Adenylate Cyclase Inhibitory Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 CREB Phosphorylation Through The Activation Of Adenylate Cyclase Pathway antibodies  CREB Phosphorylation Through The Activation Of Adenylate Cyclase Pathway Diagram
 Ca-dependent Events Pathway antibodies  Ca-dependent Events Pathway Diagram
 CaM Pathway antibodies  CaM Pathway Diagram
 Disease Name  Pubmed Publications
 Mood Disorders Antibodies  >5 publications with ADCY8 and Mood Disorders
 Bipolar Disorder Antibodies  >4 publications with ADCY8 and Bipolar Disorder
 Cardiovascular Diseases Antibodies  >1 publications with ADCY8 and Cardiovascular Diseases
 Lung Injury Antibodies  >1 publications with ADCY8 and Lung Injury
 Respiratory Tract Diseases Antibodies  >1 publications with ADCY8 and Respiratory Tract Diseases
 Brain Diseases Antibodies  >1 publications with ADCY8 and Brain Diseases
 Inflammation Antibodies  >1 publications with ADCY8 and Inflammation
Organs/Tissues associated with anti-ADCY8 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with ADCY8 and Brain
 Embryonic Tissue Antibodies  >2 publications with ADCY8 and Embryonic Tissue
 Blood Antibodies  >2 publications with ADCY8 and Blood
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