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anti-ADAM10 antibody :: Rabbit anti-Human A Disintegrin And Metalloprotease 10 (ADAM10) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2002720 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $165 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $310 +1 FREE 8GB USB
1 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloprotease 10 (ADAM10), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10)

 Product Gene Name   

anti-ADAM10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- R ATSGDKLNNN KFSLCSIRNI SQVLEKKRNN CFVESGQPIC GNGMVEQGEE CDCGYSDQCK DECCFDANQP EGRKCKLKPG KQCSPSQGPC CTAQCAFKSK SEKCRDDSDC AREGICNGFT ALCPASDPKP NFTDCNRHTQ VCINGQCAGS ICEKYGLEEC TCASSDGKDD KELCHVCCMK KMDPSTCAST GSVQWSRHFS GRTITLQPGS PCNDFRGYCD V
 OMIM    AF009615 mRNA
 3D Structure    ModBase 3D Structure for O14672
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against ADAM10. It has been selected for its ability to recognize ADAM10 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant ADAM10 (Arg420~Val641) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2047073
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-ADAM10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADAM10 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ADAM10 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-ADAM10 antibody    (Figure. Western Blot; Sample: Human Placenta Tissue.)
anti-ADAM10 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-ADAM10 antibody    (Figure. Western Blot; Sample: Recombinant ADAM10, Human.)
anti-ADAM10 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ADAM10 antibody    (Figure. DAB staining on IHC-P; Samples: Human Stomach Tissue.)
anti-ADAM10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ADAM10 antibody    (Figure. DAB staining on IHC-P; Samples: Human Stomach Cancer Tissue.)
anti-ADAM10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ADAM10 antibody    (Figure. HE staining on IHC-P;;Samples: Human Kidney Tissue.)
anti-ADAM10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ADAM10 antibody    (Figure. HE staining on IHC-P;;Samples: Human Liver Tissue.)
anti-ADAM10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ADAM10 antibody    (Figure. DAB staining on IHC-P; Samples: Human Kidney Tissue.)
anti-ADAM10 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ADAM10. It may not necessarily be applicable to this product.
 NCBI GI #    4557251
 NCBI GeneID    102
 NCBI Accession #    NP_001101.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001110.3 [Other Products]
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 UniProt Primary Accession #    O14672 [Other Products]
 UniProt Secondary Accession #    Q10742; Q92650; B4DU28 [Other Products]
 UniProt Related Accession #    O14672 [Other Products]
 Molecular Weight    49,047 Da
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 10
 NCBI Official Symbol    ADAM10 [Similar Products]
 NCBI Official Synonym Symbols   
RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 10
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 10
 UniProt Synonym Protein Names   
CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD_antigen: CD156c
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM10 [Similar Products]
 UniProt Synonym Gene Names    KUZ; MADM; ADAM 10 [Similar Products]
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 NCBI Summary for ADAM10    Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
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 UniProt Comments for ADAM10    ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Protein type: Cell adhesion; Cell surface; EC 3.4.24.81; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle

Chromosomal Location of Human Ortholog: 15q21.3

Cellular Component: cell surface; cytoplasm; endoplasmic reticulum lumen; extracellular exosome; focal adhesion; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; integral component of membrane; membrane; nucleus; plasma membrane; postsynaptic density

Molecular Function: endopeptidase activity; integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein homodimerization activity; protein kinase binding; receptor binding; SH3 domain binding

Biological Process: cell-cell signaling; cellular protein metabolic process; constitutive protein ectodomain proteolysis; extracellular matrix disassembly; in utero embryonic development; integrin-mediated signaling pathway; membrane protein ectodomain proteolysis; monocyte activation; negative regulation of cell adhesion; neutrophil degranulation; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of T cell chemotaxis; post-translational protein modification; protein amino acid phosphorylation; protein processing; response to tumor necrosis factor

Disease: Alzheimer Disease 18; Reticulate Acropigmentation Of Kitamura
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 Research Articles on ADAM10    1. Results found ADAM10 expression under the regulation of MIR-655 which binds the 3'-UTR of ADAM10 mediating the progression of hepatocellular carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAM10 antibodyPathways associated with anti-ADAM10 antibody
 Reference Product  PubMed Publications
 EGFR antibody  >37 publications with ADAM10 and EGFR
 NOTCH1 antibody  >18 publications with ADAM10 and NOTCH1
 CTNNB1 antibody  >15 publications with ADAM10 and CTNNB1
 CDH2 antibody  >6 publications with ADAM10 and CDH2
 NOTCH3 antibody  >3 publications with ADAM10 and NOTCH3
 NOTCH2 antibody  >3 publications with ADAM10 and NOTCH2
 DLL1 antibody  >3 publications with ADAM10 and DLL1
 JAG1 antibody  >2 publications with ADAM10 and JAG1
 JAG2 antibody  >1 publications with ADAM10 and JAG2
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
Diseases associated with anti-ADAM10 antibodyOrgans/Tissues associated with anti-ADAM10 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >212 publications with ADAM10 and Necrosis
 Inflammation Antibodies  >62 publications with ADAM10 and Inflammation
 Disease Models, Animal Antibodies  >48 publications with ADAM10 and Disease Models, Animal
 Skin Diseases Antibodies  >32 publications with ADAM10 and Skin Diseases
 Cardiovascular Diseases Antibodies  >23 publications with ADAM10 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >20 publications with ADAM10 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >19 publications with ADAM10 and Kidney Diseases
 Breast Neoplasms Antibodies  >18 publications with ADAM10 and Breast Neoplasms
 Lung Diseases Antibodies  >16 publications with ADAM10 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >14 publications with ADAM10 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >161 publications with ADAM10 and Brain
 Kidney Antibodies  >41 publications with ADAM10 and Kidney
 Embryonic Tissue Antibodies  >37 publications with ADAM10 and Embryonic Tissue
 Bone Antibodies  >26 publications with ADAM10 and Bone
 Skin Antibodies  >25 publications with ADAM10 and Skin
 Lung Antibodies  >24 publications with ADAM10 and Lung
 Liver Antibodies  >20 publications with ADAM10 and Liver
 Intestine Antibodies  >10 publications with ADAM10 and Intestine
 Testis Antibodies  >7 publications with ADAM10 and Testis
 Placenta Antibodies  >7 publications with ADAM10 and Placenta
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