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anti-ADAM10 antibody :: Rabbit anti-Rat A Disintegrin And Metalloprotease 10 (ADAM10) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004491 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $330 +1 FREE 8GB USB
1 mg  /  $785 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloprotease 10 (ADAM10), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10)

 Product Gene Name   

anti-ADAM10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-TSG DKLNNNKFSL CSIRNISQVL EKKRNNCFVE SGQPICGNGM VEQGEECDCG YSDQCKDECC FDANQPEGKK CKLKPGKQCS PSQGPCCTAQ CAFKSKSEKC RDDSDCAKEG ICNGFTALCP ASDPKPNFTD CNRHTQVCIN GQCAGSICEK YDLEECTCAS SDGKDDKELC HVCCMKKMAP STCASTGSLQ WNKQFTGRTI TLQPGSPCND FRGYCDVFMR CRLVD
 3D Structure    ModBase 3D Structure for Q10743
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    The antibody is a rabbit polyclonal antibody raised against ADAM10. It has been selected for its ability to recognize ADAM10 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant ADAM10 (Thr218~Asp445) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2047079
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-ADAM10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADAM10 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ADAM10 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-ADAM10 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-ADAM10 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ADAM10 antibody    (DAB staining on IHC-P; Samples: Rat Spinal cord Tissue)
anti-ADAM10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ADAM10 antibody    (Used in DAB staining on formalin fixed paraffin- embedded kidney tissue)
anti-ADAM10 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ADAM10. It may not necessarily be applicable to this product.
 NCBI GI #    37096570
 NCBI GeneID    29650
 NCBI Accession #    Q10743.1 [Other Products]
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 UniProt Primary Accession #    Q10743 [Other Products]
 UniProt Related Accession #    Q10743 [Other Products]
 Molecular Weight    60,445 Da
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 NCBI Official Full Name    Disintegrin and metalloproteinase domain-containing protein 10
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 10
 NCBI Official Symbol    Adam10 [Similar Products]
 NCBI Official Synonym Symbols   
MADM
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 10
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 10
 UniProt Synonym Protein Names   
Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD_antigen: CD156c
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    Adam10 [Similar Products]
 UniProt Synonym Gene Names    Madm; ADAM 10 [Similar Products]
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 NCBI Summary for ADAM10    may act as a disintegrin-metalloprotease related to the reprolysin family [RGD, Feb 2006]
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 UniProt Comments for ADAM10    ADAM10: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity)

Protein type: Cell adhesion; Cell surface; EC 3.4.24.81; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: cell surface; cytoplasm; dendrite; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; integral component of membrane; membrane; nucleus; plasma membrane; postsynaptic density; trans-Golgi network

Molecular Function: endopeptidase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; protein homodimerization activity; protein kinase binding; SH3 domain binding

Biological Process: amyloid-beta formation; constitutive protein ectodomain proteolysis; in utero embryonic development; membrane protein ectodomain proteolysis; monocyte activation; negative regulation of cell adhesion; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; protein amino acid phosphorylation; protein processing; regulation of osteoclast differentiation
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 Research Articles on ADAM10    1. TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAM10 antibodyPathways associated with anti-ADAM10 antibody
 Reference Product  PubMed Publications
 Bace1 antibody  >115 publications with ADAM10 and Bace1
 Notch1 antibody  >24 publications with ADAM10 and Notch1
 Aplp2 antibody  >8 publications with ADAM10 and Aplp2
 Cdh2 antibody  >7 publications with ADAM10 and Cdh2
 Notch2 antibody  >5 publications with ADAM10 and Notch2
 Erbb4 antibody  >4 publications with ADAM10 and Erbb4
 Tspan33 antibody  >3 publications with ADAM10 and Tspan33
 Dll1 antibody  >3 publications with ADAM10 and Dll1
 Tspan12 antibody  >2 publications with ADAM10 and Tspan12
 Xbp1 antibody  >1 publications with ADAM10 and Xbp1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies  EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
Organs/Tissues associated with anti-ADAM10 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >184 publications with ADAM10 and Brain
 Lung Antibodies  >31 publications with ADAM10 and Lung
 Eye Antibodies  >20 publications with ADAM10 and Eye
 Colon Antibodies  >10 publications with ADAM10 and Colon
 Spleen Antibodies  >8 publications with ADAM10 and Spleen
 Ovary Antibodies  >6 publications with ADAM10 and Ovary
 Inner Ear Antibodies  >2 publications with ADAM10 and Inner Ear
 Pineal Gland Antibodies  >1 publications with ADAM10 and Pineal Gland
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