Q10743.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
60,445 Da
NCBI Official Full Name
Disintegrin and metalloproteinase domain-containing protein 10
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 10
NCBI Official Synonym Symbols
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 10
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 10
UniProt Synonym Protein Names
Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD_antigen: CD156c
UniProt Synonym Gene Names
NCBI Summary for ADAM10
may act as a disintegrin-metalloprotease related to the reprolysin family [RGD, Feb 2006]
UniProt Comments for ADAM10
ADAM10: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity)
Protein type: Cell adhesion; Cell surface; EC 3.4.24.81; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: cell surface; cytoplasm; dendrite; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; integral component of membrane; membrane; nucleus; plasma membrane; postsynaptic density; trans-Golgi network
Molecular Function: endopeptidase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; protein homodimerization activity; protein kinase binding; SH3 domain binding
Biological Process: amyloid-beta formation; constitutive protein ectodomain proteolysis; in utero embryonic development; membrane protein ectodomain proteolysis; monocyte activation; negative regulation of cell adhesion; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; protein amino acid phosphorylation; protein processing; regulation of osteoclast differentiation
Research Articles on ADAM10
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Products associated with anti-ADAM10 antibody
Pathways associated with anti-ADAM10 antibody
Organs/Tissues associated with anti-ADAM10 antibody
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