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anti-ADAM10 antibody :: anti-Rat A Disintegrin And Metalloprotease 10 (ADAM10) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2015509 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-ADAM10 antibody
Unit / Price
0.1 mg  /  $415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloprotease 10 (ADAM10), Polyclonal Antibody

 Also Known As   

FITC-linked Antibody to A Disintegrin And Metalloprotease 10 (ADAM10)

 Product Gene Name   

anti-ADAM10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (8645124..8675588, complement). Location: 19p13.2
 OMIM    277600
 3D Structure    ModBase 3D Structure for Q9H324
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 Clonality    Polyclonal
 Species Reactivity    Rat
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 Concentration    200ug/ml (lot specific)
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-ADAM10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ADAM10 antibody    FITC Antibody
 Applications Tested/Suitable for anti-ADAM10 antibody   

Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ADAM10. It may not necessarily be applicable to this product.
 NCBI GI #    537544566
 NCBI GeneID    81794
 NCBI Accession #    NP_112219.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_030957.3 [Other Products]
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 UniProt Primary Accession #    Q9H324 [Other Products]
 UniProt Related Accession #    Q9H324 [Other Products]
 Molecular Weight    120,874 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 1 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 10
 NCBI Official Symbol    ADAMTS10 [Similar Products]
 NCBI Official Synonym Symbols   
WMS; WMS1; ADAM-TS10; ADAMTS-10
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 10; ADAM-TS 10; zinc metalloendopeptidase; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 10
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAMTS10 [Similar Products]
 UniProt Synonym Gene Names    ADAM-TS 10; ADAM-TS10; ADAMTS-10 [Similar Products]
 UniProt Entry Name    ATS10_HUMAN
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 NCBI Summary for ADAM10    This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAM10    ADAMTS10: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1). WMS1 is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.

Protein type: Secreted, signal peptide; EC 3.4.24.-; Protease; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular matrix; microfibril

Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity

Biological Process: proteolysis

Disease: Weill-marchesani Syndrome 1
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 Research Articles on ADAM10    1. These findings support the Gly661Arg mutation of ADAMTS10 as the likely cause of POAG in beagles.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAM10 antibodyDiseases associated with anti-ADAM10 antibody
 Reference Product  PubMed Publications
 FBN1 antibody  >8 publications with ADAM10 and FBN1
 LTBP1 antibody  >1 publications with ADAM10 and LTBP1
 Disease Name  Pubmed Publications
 Weill-Marchesani Syndrome Antibodies  >13 publications with ADAM10 and Weill-Marchesani Syndrome
 Pregnancy Complications Antibodies  >1 publications with ADAM10 and Pregnancy Complications
 Kidney Diseases Antibodies  >1 publications with ADAM10 and Kidney Diseases
 Heart Diseases Antibodies  >1 publications with ADAM10 and Heart Diseases
Organs/Tissues associated with anti-ADAM10 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >9 publications with ADAM10 and Eye
 Skin Antibodies  >3 publications with ADAM10 and Skin
 Blood Antibodies  >2 publications with ADAM10 and Blood
 Heart Antibodies  >2 publications with ADAM10 and Heart
 Kidney Antibodies  >2 publications with ADAM10 and Kidney
 Nerve Antibodies  >1 publications with ADAM10 and Nerve
 Lung Antibodies  >1 publications with ADAM10 and Lung
 Embryonic Tissue Antibodies  >1 publications with ADAM10 and Embryonic Tissue
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